Experimental infection of nude mice as a model for Sarcocystis neurona- associated encephalitis

Antoinette E. Marsh, Bradd C. Barr, Jeffrey Lakritz, Robert Nordhausen, John E Madigan, Patricia A Conrad

Research output: Contribution to journalArticle

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Abstract

The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoa parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.

Original languageEnglish (US)
Pages (from-to)706-711
Number of pages6
JournalParasitology Research
Volume83
Issue number7
DOIs
StatePublished - 1997

Fingerprint

Sarcocystis
Sarcocystis neurona
Encephalitis
encephalitis
Nude Mice
Parasites
mice
Infection
parasites
infection
Neospora
Toxoplasma
Neospora caninum
Rodentia
Animal Models
Toxoplasma gondii
Immunohistochemistry
histopathology
immunohistochemistry
Protozoa

ASJC Scopus subject areas

  • Parasitology

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Experimental infection of nude mice as a model for Sarcocystis neurona- associated encephalitis. / Marsh, Antoinette E.; Barr, Bradd C.; Lakritz, Jeffrey; Nordhausen, Robert; Madigan, John E; Conrad, Patricia A.

In: Parasitology Research, Vol. 83, No. 7, 1997, p. 706-711.

Research output: Contribution to journalArticle

Marsh, Antoinette E. ; Barr, Bradd C. ; Lakritz, Jeffrey ; Nordhausen, Robert ; Madigan, John E ; Conrad, Patricia A. / Experimental infection of nude mice as a model for Sarcocystis neurona- associated encephalitis. In: Parasitology Research. 1997 ; Vol. 83, No. 7. pp. 706-711.
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