Experimental infection of nude mice as a model for Sarcocystis neurona- associated encephalitis

Antoinette E. Marsh, Bradd C. Barr, Jeffrey Lakritz, Robert Nordhausen, John E Madigan, Patricia A Conrad

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65 Scopus citations


The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoa parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.

Original languageEnglish (US)
Pages (from-to)706-711
Number of pages6
JournalParasitology Research
Issue number7
StatePublished - 1997

ASJC Scopus subject areas

  • Parasitology


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