Abstract
The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoa parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 706-711 |
| Number of pages | 6 |
| Journal | Parasitology Research |
| Volume | 83 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1997 |
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- Parasitology
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Experimental infection of nude mice as a model for Sarcocystis neurona- associated encephalitis. / Marsh, Antoinette E.; Barr, Bradd C.; Lakritz, Jeffrey; Nordhausen, Robert; Madigan, John E; Conrad, Patricia A.
In: Parasitology Research, Vol. 83, No. 7, 1997, p. 706-711.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental infection of nude mice as a model for Sarcocystis neurona- associated encephalitis
AU - Marsh, Antoinette E.
AU - Barr, Bradd C.
AU - Lakritz, Jeffrey
AU - Nordhausen, Robert
AU - Madigan, John E
AU - Conrad, Patricia A
PY - 1997
Y1 - 1997
N2 - The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoa parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.
AB - The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoa parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.
UR - http://www.scopus.com/inward/record.url?scp=0030756856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030756856&partnerID=8YFLogxK
U2 - 10.1007/s004360050323
DO - 10.1007/s004360050323
M3 - Article
C2 - 9272562
AN - SCOPUS:0030756856
VL - 83
SP - 706
EP - 711
JO - Zeitschrift fur Parasitenkunde
JF - Zeitschrift fur Parasitenkunde
SN - 0932-0113
IS - 7
ER -