The medical treatment of chronic gastric ulcer is unsatisfactory. Many new therapeutic regimens are being tried. Human gastric ulcer has a variable and unpredictable course, making it difficult to evaluate and compare the efficacy of various therapeutic modalities. Previous animal models have been unsatisfactory because of lack of reproducibility; moreover the site, size, and number of gastric ulcers produced could neither be predicted nor be controlled. In the present experimental model we produced a single gastric ulcer in each rat on the posterior surface of the body of the stomach; the ulcer was of a definite size (16 mm.2) and produced by applying a known definite amount of electric energy. These ulcers were evaluated grossly and microscopically over a period of one week. At one week after electrocoagulation, the ulcers resembled chronic gastric ulcer in the humans. We feel it will prove a suitable experimental model to study the effects of anti-ulcer drugs.
|Original language||English (US)|
|Title of host publication||American Journal of Proctology Gastroenterology and Colon and Rectal Surgery|
|State||Published - 1982|
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