Abstract
Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data, including the presence of autoantibodies and autoreactive T cells. The etiology remains to be determined, yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset. Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host, mostly by molecular mimicry. Most recently, several murine models have been reported, including genetically determined models as well as models induced by immunization with xenobiotics and bacteria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Cellular and Molecular Immunology |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
Experimental evidence on the immunopathogenesis of primary biliary cirrhosis. / Selmi, Carlo; Meda, Francesca; Kasangian, Anaid; Invernizzi, Pietro; Tian, Zhigang; Lian, Zhexiong; Podda, Mauro; Gershwin, M. Eric.
In: Cellular and Molecular Immunology, Vol. 7, No. 1, 01.2010, p. 1-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental evidence on the immunopathogenesis of primary biliary cirrhosis
AU - Selmi, Carlo
AU - Meda, Francesca
AU - Kasangian, Anaid
AU - Invernizzi, Pietro
AU - Tian, Zhigang
AU - Lian, Zhexiong
AU - Podda, Mauro
AU - Gershwin, M. Eric
PY - 2010/1
Y1 - 2010/1
N2 - Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data, including the presence of autoantibodies and autoreactive T cells. The etiology remains to be determined, yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset. Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host, mostly by molecular mimicry. Most recently, several murine models have been reported, including genetically determined models as well as models induced by immunization with xenobiotics and bacteria.
AB - Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data, including the presence of autoantibodies and autoreactive T cells. The etiology remains to be determined, yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset. Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host, mostly by molecular mimicry. Most recently, several murine models have been reported, including genetically determined models as well as models induced by immunization with xenobiotics and bacteria.
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U2 - 10.1038/cmi.2009.104
DO - 10.1038/cmi.2009.104
M3 - Article
C2 - 20029462
AN - SCOPUS:75949084877
VL - 7
SP - 1
EP - 10
JO - Cellular and Molecular Immunology
JF - Cellular and Molecular Immunology
SN - 1672-7681
IS - 1
ER -