Experimental Corynebacterium kutscheri infection in rats: bacteriology and serology.

D. G. Brownstein, Stephen W Barthold, R. L. Adams, G. A. Terwilliger, J. G. Aftosmis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In a preliminary study, hydrocortisone-treated rats developed pseudotuberculosis when challenged with 6.2 X 10(5) to 3.1 X 10(7) colony forming units of Corynebacterium kutscheri by intranasal, intragastric, or subcutaneous inoculation. Oronasal exposure was selected as a likely natural route to further study inapparent infection. In Study 1, 50 rats received 1.2 X 10(5) colony forming units and various tissues were cultured at intervals to 12 weeks post-inoculation. At each interval, C. kutscheri was regularly isolated from submaxillary lymph nodes, but isolation was sporadic from other sites. In Study 2, 17 out of 21 rats given 1.2 X 10(5) colony forming units and killed weekly for 6 weeks had 2.0 X 10(2) to 1.8 X 10(5) colony forming units of C. kutscheri in oral washes, and 16 rats had 2.0 X 10(2) to 1.0 X 10(5) colony forming units in submaxillary lymph nodes, Serum antibody to C. kutscheri using both microagglutination and indirect immunofluorescence was first detected in some rats by 2 weeks, and in all rats at subsequent intervals. There was a significant (P less than 0.001) positive correlation (r = 0.93) between serum antibody titers and the duration of infection.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalLaboratory animal science Chicago
Volume35
Issue number2
StatePublished - Apr 1985
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Brownstein, D. G., Barthold, S. W., Adams, R. L., Terwilliger, G. A., & Aftosmis, J. G. (1985). Experimental Corynebacterium kutscheri infection in rats: bacteriology and serology. Laboratory animal science Chicago, 35(2), 135-138.