Experimental Corynebacterium kutscheri infection in rats

bacteriology and serology.

D. G. Brownstein, Stephen W Barthold, R. L. Adams, G. A. Terwilliger, J. G. Aftosmis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In a preliminary study, hydrocortisone-treated rats developed pseudotuberculosis when challenged with 6.2 X 10(5) to 3.1 X 10(7) colony forming units of Corynebacterium kutscheri by intranasal, intragastric, or subcutaneous inoculation. Oronasal exposure was selected as a likely natural route to further study inapparent infection. In Study 1, 50 rats received 1.2 X 10(5) colony forming units and various tissues were cultured at intervals to 12 weeks post-inoculation. At each interval, C. kutscheri was regularly isolated from submaxillary lymph nodes, but isolation was sporadic from other sites. In Study 2, 17 out of 21 rats given 1.2 X 10(5) colony forming units and killed weekly for 6 weeks had 2.0 X 10(2) to 1.8 X 10(5) colony forming units of C. kutscheri in oral washes, and 16 rats had 2.0 X 10(2) to 1.0 X 10(5) colony forming units in submaxillary lymph nodes, Serum antibody to C. kutscheri using both microagglutination and indirect immunofluorescence was first detected in some rats by 2 weeks, and in all rats at subsequent intervals. There was a significant (P less than 0.001) positive correlation (r = 0.93) between serum antibody titers and the duration of infection.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalLaboratory animal science Chicago
Volume35
Issue number2
StatePublished - Apr 1985
Externally publishedYes

Fingerprint

Corynebacterium kutscheri
Bacteriology
Corynebacterium Infections
bacteriology
Serology
Rats
Stem Cells
rats
infection
blood serum
lymph nodes
Lymph Nodes
Corynebacterium
antibodies
Antibodies
Indirect Fluorescent Antibody Technique
Infection
Serum
fluorescent antibody technique
cortisol

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Brownstein, D. G., Barthold, S. W., Adams, R. L., Terwilliger, G. A., & Aftosmis, J. G. (1985). Experimental Corynebacterium kutscheri infection in rats: bacteriology and serology. Laboratory animal science Chicago, 35(2), 135-138.

Experimental Corynebacterium kutscheri infection in rats : bacteriology and serology. / Brownstein, D. G.; Barthold, Stephen W; Adams, R. L.; Terwilliger, G. A.; Aftosmis, J. G.

In: Laboratory animal science Chicago, Vol. 35, No. 2, 04.1985, p. 135-138.

Research output: Contribution to journalArticle

Brownstein, DG, Barthold, SW, Adams, RL, Terwilliger, GA & Aftosmis, JG 1985, 'Experimental Corynebacterium kutscheri infection in rats: bacteriology and serology.', Laboratory animal science Chicago, vol. 35, no. 2, pp. 135-138.
Brownstein, D. G. ; Barthold, Stephen W ; Adams, R. L. ; Terwilliger, G. A. ; Aftosmis, J. G. / Experimental Corynebacterium kutscheri infection in rats : bacteriology and serology. In: Laboratory animal science Chicago. 1985 ; Vol. 35, No. 2. pp. 135-138.
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