Experimental congenital infection of Toxoplasma gondii in Macaca arctoides.

M. M. Wong, W. J. Kozek, S. L. Karr, M. A. Brayton, J. H. Theis, Andrew G Hendrickx

Research output: Contribution to journalArticle

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Abstract

Congenital toxoplasmosis was studied in Macaca arctoides as a model for primates. Time-mated female monkeys were assigned to 5 experimental groups and inoculated with 4 different strains of Toxoplasma gondii before pregnancy and during various stages of gestation. All monkeys showed a rise in indirect hemagglutination antibody (IHA) titers following infection, and some had demonstrable parasitemia. Of the 23 progeny, 2 were stillbirths and 2 died soon after birth, but only the one neonate born of a mother inoculated intrauterally succumbed to acute toxoplasmosis. No physical anomalies were observed in any of the progeny. The toxoplasms organism was not isolated from any of the placentas obtained nor from the cord blood. None of the tissues from the stillborn or infant monkeys that died were positive for toxoplasmosis by mouse inoculation. The live progeny were usually born with high IHA antibody titers which were usually soon lost, indicating presence of passively acquired maternal antibody. However, 2 babies, born of mothers infected with tissue cysts on day 79 and 149 of gestation, maintained moderate to high titers for about 8 and 19 months respectively, indicating that an active infection had taken place but no clinical disease was detected. Data obtained suggest that although certain developmental stages of the toxoplasma organism and of the fetus may favor the occurrence of congenital infection, very little neonatal disease results in this primate model.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalAsian journal of infectious diseases
Volume3
Issue number2
StatePublished - Jun 1979

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Congenital Toxoplasmosis
Macaca
Haplorhini
Antibodies
Toxoplasmosis
Toxoplasma
Mothers
Hemagglutination
Pregnancy
Primates
Infant, Newborn, Diseases
Infection
Stillbirth
Parasitemia
Cerebral Palsy
Fetal Blood
Placenta
Cysts
Fetus
Parturition

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wong, M. M., Kozek, W. J., Karr, S. L., Brayton, M. A., Theis, J. H., & Hendrickx, A. G. (1979). Experimental congenital infection of Toxoplasma gondii in Macaca arctoides. Asian journal of infectious diseases, 3(2), 61-67.

Experimental congenital infection of Toxoplasma gondii in Macaca arctoides. / Wong, M. M.; Kozek, W. J.; Karr, S. L.; Brayton, M. A.; Theis, J. H.; Hendrickx, Andrew G.

In: Asian journal of infectious diseases, Vol. 3, No. 2, 06.1979, p. 61-67.

Research output: Contribution to journalArticle

Wong, MM, Kozek, WJ, Karr, SL, Brayton, MA, Theis, JH & Hendrickx, AG 1979, 'Experimental congenital infection of Toxoplasma gondii in Macaca arctoides.', Asian journal of infectious diseases, vol. 3, no. 2, pp. 61-67.
Wong MM, Kozek WJ, Karr SL, Brayton MA, Theis JH, Hendrickx AG. Experimental congenital infection of Toxoplasma gondii in Macaca arctoides. Asian journal of infectious diseases. 1979 Jun;3(2):61-67.
Wong, M. M. ; Kozek, W. J. ; Karr, S. L. ; Brayton, M. A. ; Theis, J. H. ; Hendrickx, Andrew G. / Experimental congenital infection of Toxoplasma gondii in Macaca arctoides. In: Asian journal of infectious diseases. 1979 ; Vol. 3, No. 2. pp. 61-67.
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