Experimental challenge models for Johne's disease: A review and proposed international guidelines

Murray E. Hines; Judith R. Stabel; Raymond W. Sweeney; Frank Griffin; Adel M. Talaat; Douwe Bakker; Geart Benedictus; William C. Davis; Geoffrey W. de Lisle; Ian Gardner; Ramon A. Juste; Vivek Kapur; Ad Koets; Jim McNair; Greg Pruitt; Robert H. Whitlock

doi:10.1016/j.vetmic.2007.03.009

Experimental challenge models for Johne's disease: A review and proposed international guidelines

Murray E. Hines, Judith R. Stabel, Raymond W. Sweeney, Frank Griffin, Adel M. Talaat, Douwe Bakker, Geart Benedictus, William C. Davis, Geoffrey W. de Lisle, Ian Gardner, Ramon A. Juste, Vivek Kapur, Ad Koets, Jim McNair, Greg Pruitt, Robert H. Whitlock

School of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

95 Scopus citations

Abstract

An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.

Original language	English (US)
Pages (from-to)	197-222
Number of pages	26
Journal	Veterinary Microbiology
Volume	122
Issue number	3-4
DOIs	https://doi.org/10.1016/j.vetmic.2007.03.009
State	Published - Jun 21 2007

Keywords

Animal models
Challenge
Experimental infection
Johne's disease
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis

ASJC Scopus subject areas

Microbiology
veterinary(all)

Access to Document

10.1016/j.vetmic.2007.03.009

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Hines, M. E., Stabel, J. R., Sweeney, R. W., Griffin, F., Talaat, A. M., Bakker, D., Benedictus, G., Davis, W. C., de Lisle, G. W., Gardner, I., Juste, R. A., Kapur, V., Koets, A., McNair, J., Pruitt, G., & Whitlock, R. H. (2007). Experimental challenge models for Johne's disease: A review and proposed international guidelines. Veterinary Microbiology, 122(3-4), 197-222. https://doi.org/10.1016/j.vetmic.2007.03.009

Experimental challenge models for Johne's disease : A review and proposed international guidelines. / Hines, Murray E.; Stabel, Judith R.; Sweeney, Raymond W.; Griffin, Frank; Talaat, Adel M.; Bakker, Douwe; Benedictus, Geart; Davis, William C.; de Lisle, Geoffrey W.; Gardner, Ian; Juste, Ramon A.; Kapur, Vivek; Koets, Ad; McNair, Jim; Pruitt, Greg; Whitlock, Robert H.

In: Veterinary Microbiology, Vol. 122, No. 3-4, 21.06.2007, p. 197-222.

Research output: Contribution to journal › Review article › peer-review

Hines, ME, Stabel, JR, Sweeney, RW, Griffin, F, Talaat, AM, Bakker, D, Benedictus, G, Davis, WC, de Lisle, GW, Gardner, I, Juste, RA, Kapur, V, Koets, A, McNair, J, Pruitt, G & Whitlock, RH 2007, 'Experimental challenge models for Johne's disease: A review and proposed international guidelines', Veterinary Microbiology, vol. 122, no. 3-4, pp. 197-222. https://doi.org/10.1016/j.vetmic.2007.03.009

Hines, Murray E. ; Stabel, Judith R. ; Sweeney, Raymond W. ; Griffin, Frank ; Talaat, Adel M. ; Bakker, Douwe ; Benedictus, Geart ; Davis, William C. ; de Lisle, Geoffrey W. ; Gardner, Ian ; Juste, Ramon A. ; Kapur, Vivek ; Koets, Ad ; McNair, Jim ; Pruitt, Greg ; Whitlock, Robert H. / Experimental challenge models for Johne's disease : A review and proposed international guidelines. In: Veterinary Microbiology. 2007 ; Vol. 122, No. 3-4. pp. 197-222.

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