Experimental challenge models for Johne's disease: A review and proposed international guidelines

Murray E. Hines, Judith R. Stabel, Raymond W. Sweeney, Frank Griffin, Adel M. Talaat, Douwe Bakker, Geart Benedictus, William C. Davis, Geoffrey W. de Lisle, Ian Gardner, Ramon A. Juste, Vivek Kapur, Ad Koets, Jim McNair, Greg Pruitt, Robert H. Whitlock

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.

Original languageEnglish (US)
Pages (from-to)197-222
Number of pages26
JournalVeterinary Microbiology
Volume122
Issue number3-4
DOIs
StatePublished - Jun 21 2007

Fingerprint

Paratuberculosis
paratuberculosis
Theoretical Models
Guidelines
animals
Mycobacterium avium subsp. paratuberculosis
host-pathogen relationships
disease models
dosage
endpoints
Host-Pathogen Interactions
Mycobacterium avium
committees
quality control
laboratory animals
inoculum
researchers
immunity
goats
Goats

Keywords

  • Animal models
  • Challenge
  • Experimental infection
  • Johne's disease
  • Mycobacterium avium subsp. paratuberculosis
  • Paratuberculosis

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Hines, M. E., Stabel, J. R., Sweeney, R. W., Griffin, F., Talaat, A. M., Bakker, D., ... Whitlock, R. H. (2007). Experimental challenge models for Johne's disease: A review and proposed international guidelines. Veterinary Microbiology, 122(3-4), 197-222. https://doi.org/10.1016/j.vetmic.2007.03.009

Experimental challenge models for Johne's disease : A review and proposed international guidelines. / Hines, Murray E.; Stabel, Judith R.; Sweeney, Raymond W.; Griffin, Frank; Talaat, Adel M.; Bakker, Douwe; Benedictus, Geart; Davis, William C.; de Lisle, Geoffrey W.; Gardner, Ian; Juste, Ramon A.; Kapur, Vivek; Koets, Ad; McNair, Jim; Pruitt, Greg; Whitlock, Robert H.

In: Veterinary Microbiology, Vol. 122, No. 3-4, 21.06.2007, p. 197-222.

Research output: Contribution to journalReview article

Hines, ME, Stabel, JR, Sweeney, RW, Griffin, F, Talaat, AM, Bakker, D, Benedictus, G, Davis, WC, de Lisle, GW, Gardner, I, Juste, RA, Kapur, V, Koets, A, McNair, J, Pruitt, G & Whitlock, RH 2007, 'Experimental challenge models for Johne's disease: A review and proposed international guidelines', Veterinary Microbiology, vol. 122, no. 3-4, pp. 197-222. https://doi.org/10.1016/j.vetmic.2007.03.009
Hines, Murray E. ; Stabel, Judith R. ; Sweeney, Raymond W. ; Griffin, Frank ; Talaat, Adel M. ; Bakker, Douwe ; Benedictus, Geart ; Davis, William C. ; de Lisle, Geoffrey W. ; Gardner, Ian ; Juste, Ramon A. ; Kapur, Vivek ; Koets, Ad ; McNair, Jim ; Pruitt, Greg ; Whitlock, Robert H. / Experimental challenge models for Johne's disease : A review and proposed international guidelines. In: Veterinary Microbiology. 2007 ; Vol. 122, No. 3-4. pp. 197-222.
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