Abstract
An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-222 |
| Number of pages | 26 |
| Journal | Veterinary Microbiology |
| Volume | 122 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Jun 21 2007 |
Fingerprint
Keywords
- Animal models
- Challenge
- Experimental infection
- Johne's disease
- Mycobacterium avium subsp. paratuberculosis
- Paratuberculosis
ASJC Scopus subject areas
- Microbiology
- veterinary(all)
Cite this
Experimental challenge models for Johne's disease : A review and proposed international guidelines. / Hines, Murray E.; Stabel, Judith R.; Sweeney, Raymond W.; Griffin, Frank; Talaat, Adel M.; Bakker, Douwe; Benedictus, Geart; Davis, William C.; de Lisle, Geoffrey W.; Gardner, Ian; Juste, Ramon A.; Kapur, Vivek; Koets, Ad; McNair, Jim; Pruitt, Greg; Whitlock, Robert H.
In: Veterinary Microbiology, Vol. 122, No. 3-4, 21.06.2007, p. 197-222.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Experimental challenge models for Johne's disease
T2 - A review and proposed international guidelines
AU - Hines, Murray E.
AU - Stabel, Judith R.
AU - Sweeney, Raymond W.
AU - Griffin, Frank
AU - Talaat, Adel M.
AU - Bakker, Douwe
AU - Benedictus, Geart
AU - Davis, William C.
AU - de Lisle, Geoffrey W.
AU - Gardner, Ian
AU - Juste, Ramon A.
AU - Kapur, Vivek
AU - Koets, Ad
AU - McNair, Jim
AU - Pruitt, Greg
AU - Whitlock, Robert H.
PY - 2007/6/21
Y1 - 2007/6/21
N2 - An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
AB - An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a "best fit" JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
KW - Animal models
KW - Challenge
KW - Experimental infection
KW - Johne's disease
KW - Mycobacterium avium subsp. paratuberculosis
KW - Paratuberculosis
UR - http://www.scopus.com/inward/record.url?scp=34249058961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249058961&partnerID=8YFLogxK
U2 - 10.1016/j.vetmic.2007.03.009
DO - 10.1016/j.vetmic.2007.03.009
M3 - Review article
C2 - 17467201
AN - SCOPUS:34249058961
VL - 122
SP - 197
EP - 222
JO - Veterinary Microbiology
JF - Veterinary Microbiology
SN - 0378-1135
IS - 3-4
ER -