Experimental Borrelia burgdorferi infection in Peromyscus leucopus.

K. D. Moody, G. A. Terwilliger, G. M. Hansen, Stephen W Barthold

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


We evaluated the susceptibility of laboratory-reared adult and infant white-footed mice (Peromyscus leucopus) to a known pathogenic isolate of Borrelia burgdorferi (N40). Two-month-old and 3-day-old Peromyscus were inoculated intradermally with 10(6) to 10(7) spirochetes. At 21 days for adults or 30 days for infants post inoculation, mice were killed, and tissues were cultured for spirochetes and examined microscopically. Based on serology and culture, adult mice became infected but did not have any gross or microscopic lesions. Mice inoculated as infants became infected, and also developed carditis and multifocal arthritis. Contact transmission between inoculated infants and their naive mothers was not observed. Age at inoculation appeared to be a critical factor in inducing Lyme borreliosis lesions in Peromyscus leucopus, as in other species.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalJournal of Wildlife Diseases
Issue number2
StatePublished - Apr 1994
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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