Experimental assessment of resolution improvement of a zoom-in PET

Jinyi Qi, Yongfeng Yang, Jian Zhou, Yibao Wu, Simon R Cherry

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We have proposed a zoom-in positron emission tomography (PET) system that incorporates a high-resolution detector into an existing PET scanner to obtain high-resolution images of a region of interest. Previously we have shown by computer simulations that the high-resolution detector can improve the overall system performance in terms of spatial resolution and lesion detectability. In this study, we assessed the resolution improvement in a real system by incorporating a high-resolution detector into our existing microPET II scanner. The high-resolution detector consists of a 14 × 28 array of 0.5 × 0.5 × 10 mm3 lutetium oxyorthosilicate scintillator elements and is placed near the center of the microPET II scanner. It is coupled to two 64-channel photomultiplier tubes (PMTs) via tapered optical fiber bundles. The PMT signals were read out by the electronics in the microPET II scanner. A 15 νCi Na-22 point source was positioned at various locations above the high-resolution detector. Images were reconstructed using the data measured by the microPET II scanner alone and the microPET II data combined with the high-resolution detector data. Profiles taken through the reconstructed point sources show substantial reduction in full-width-at-half-maximum along the direction parallel to the face of the high-resolution detector.

Original languageEnglish (US)
JournalPhysics in Medicine and Biology
Issue number17
StatePublished - Sep 7 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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