Abstract
Different groups of rats were given a hippocampal seizure after-discharge 1 or 7 days after acquiring a passive avoidance, active avoidance, or bar-pressing habit. At various delays after the cessation of the seizure after-discharge, the animals were tested for retention of the previously acquired habit. The results indicate that 1 day, but not 7 days after learning, hippocampal seizures are capable of producing a temporary retrograde amnesia for well-learned responses and an anterograde amnesia for experiences that occur during the retrograde amnesia period. These data suggest that hippocampal seizures can serve as an experimental prototype of "transient global amnesia" and that the hippocampus is critically involved in retrieval of information from long term memory.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 465-480 |
| Number of pages | 16 |
| Journal | Neuropsychologia |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Neuropsychology and Physiological Psychology
Cite this
Experimental animal model of transient global amnesia : Role of the hippocampus. / Kesner, Raymond P.; Dixon, David A.; Pickett, Diane; Berman, Robert F.
In: Neuropsychologia, Vol. 13, No. 4, 1975, p. 465-480.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental animal model of transient global amnesia
T2 - Role of the hippocampus
AU - Kesner, Raymond P.
AU - Dixon, David A.
AU - Pickett, Diane
AU - Berman, Robert F
PY - 1975
Y1 - 1975
N2 - Different groups of rats were given a hippocampal seizure after-discharge 1 or 7 days after acquiring a passive avoidance, active avoidance, or bar-pressing habit. At various delays after the cessation of the seizure after-discharge, the animals were tested for retention of the previously acquired habit. The results indicate that 1 day, but not 7 days after learning, hippocampal seizures are capable of producing a temporary retrograde amnesia for well-learned responses and an anterograde amnesia for experiences that occur during the retrograde amnesia period. These data suggest that hippocampal seizures can serve as an experimental prototype of "transient global amnesia" and that the hippocampus is critically involved in retrieval of information from long term memory.
AB - Different groups of rats were given a hippocampal seizure after-discharge 1 or 7 days after acquiring a passive avoidance, active avoidance, or bar-pressing habit. At various delays after the cessation of the seizure after-discharge, the animals were tested for retention of the previously acquired habit. The results indicate that 1 day, but not 7 days after learning, hippocampal seizures are capable of producing a temporary retrograde amnesia for well-learned responses and an anterograde amnesia for experiences that occur during the retrograde amnesia period. These data suggest that hippocampal seizures can serve as an experimental prototype of "transient global amnesia" and that the hippocampus is critically involved in retrieval of information from long term memory.
UR - http://www.scopus.com/inward/record.url?scp=0016825952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016825952&partnerID=8YFLogxK
U2 - 10.1016/0028-3932(75)90070-6
DO - 10.1016/0028-3932(75)90070-6
M3 - Article
C2 - 1238953
AN - SCOPUS:0016825952
VL - 13
SP - 465
EP - 480
JO - Neuropsychologia
JF - Neuropsychologia
SN - 0028-3932
IS - 4
ER -