Abstract
An improved understanding of contrast agent behavior may yield more sophisticated bubble detection techniques. In this study, the optical measurements of single bubble oscillations during insonation are compared directly to theoretical predictions. These results are then used to aid in the understanding of the effects of transmission and bubble parameters on the bubble oscillations and resulting received echoes. A Rayleigh-Plesset-like bubble equation with additional shell terms is solved for the time dependent bubble radius and wall velocity, and these outputs are also used to formulate the predicted echo from a single encapsulated bubble. The experimental and theoretical radius-time curves are in good agreement; with a consistent, predictable response from the lipid-shelled agent with varying amplitude, phase and length of the transmission pulses. The radius-time curves of the albumin-shelled agent Optison are less predictable due to its asymmetric oscillations. Observations of the effects of transmitted phase and the corresponding predicted echoes are consistent with previous experimental results. These results demonstrate that the transmission of two pulses with opposite phases will yield similar time domain echoes with the echo from the pulse with rarefaction first (180°) having a mean frequency that is higher than the compression first response (0°).
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the IEEE Ultrasonics Symposium |
| Publisher | IEEE |
| Pages | 1685-1688 |
| Number of pages | 4 |
| Volume | 2 |
| State | Published - 1999 |
| Externally published | Yes |
| Event | 1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA Duration: Oct 17 1999 → Oct 20 1999 |
Other
| Other | 1999 IEEE Ultrasonics Symposium |
|---|---|
| City | Caesars Tahoe, NV, USA |
| Period | 10/17/99 → 10/20/99 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Experimental and theoretical analysis of individual contrast agent behavior. / Morgan, Karen E.; Allen, John S.; Chomas, James E.; Dayton, Paul A.; Ferrara, Katherine W.
Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 IEEE, 1999. p. 1685-1688.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Experimental and theoretical analysis of individual contrast agent behavior
AU - Morgan, Karen E.
AU - Allen, John S.
AU - Chomas, James E.
AU - Dayton, Paul A.
AU - Ferrara, Katherine W.
PY - 1999
Y1 - 1999
N2 - An improved understanding of contrast agent behavior may yield more sophisticated bubble detection techniques. In this study, the optical measurements of single bubble oscillations during insonation are compared directly to theoretical predictions. These results are then used to aid in the understanding of the effects of transmission and bubble parameters on the bubble oscillations and resulting received echoes. A Rayleigh-Plesset-like bubble equation with additional shell terms is solved for the time dependent bubble radius and wall velocity, and these outputs are also used to formulate the predicted echo from a single encapsulated bubble. The experimental and theoretical radius-time curves are in good agreement; with a consistent, predictable response from the lipid-shelled agent with varying amplitude, phase and length of the transmission pulses. The radius-time curves of the albumin-shelled agent Optison are less predictable due to its asymmetric oscillations. Observations of the effects of transmitted phase and the corresponding predicted echoes are consistent with previous experimental results. These results demonstrate that the transmission of two pulses with opposite phases will yield similar time domain echoes with the echo from the pulse with rarefaction first (180°) having a mean frequency that is higher than the compression first response (0°).
AB - An improved understanding of contrast agent behavior may yield more sophisticated bubble detection techniques. In this study, the optical measurements of single bubble oscillations during insonation are compared directly to theoretical predictions. These results are then used to aid in the understanding of the effects of transmission and bubble parameters on the bubble oscillations and resulting received echoes. A Rayleigh-Plesset-like bubble equation with additional shell terms is solved for the time dependent bubble radius and wall velocity, and these outputs are also used to formulate the predicted echo from a single encapsulated bubble. The experimental and theoretical radius-time curves are in good agreement; with a consistent, predictable response from the lipid-shelled agent with varying amplitude, phase and length of the transmission pulses. The radius-time curves of the albumin-shelled agent Optison are less predictable due to its asymmetric oscillations. Observations of the effects of transmitted phase and the corresponding predicted echoes are consistent with previous experimental results. These results demonstrate that the transmission of two pulses with opposite phases will yield similar time domain echoes with the echo from the pulse with rarefaction first (180°) having a mean frequency that is higher than the compression first response (0°).
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UR - http://www.scopus.com/inward/citedby.url?scp=0033295237&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0033295237
VL - 2
SP - 1685
EP - 1688
BT - Proceedings of the IEEE Ultrasonics Symposium
PB - IEEE
ER -