Experimental and engineering approaches to intracellular communication

John Albeck, Michael Pargett, Alexander E. Davies

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Communication between and within cells is essential for multicellular life. While intracellular signal transduction pathways are often specified in molecular terms, the information content they transmit remains poorly defined. Here, we review research efforts to merge biological experimentation with concepts of communication that emerge from the engineering disciplines of signal processing and control theory. We discuss the challenges of performing experiments that quantitate information transfer at the molecular level, and we highlight recent studies that have advanced toward a clearer definition of the information content carried by signaling molecules. Across these studies, we emphasize a theme of increasingly well-matched experimental and theoretical approaches to decode the data streams directing cellular behavior.

Original languageEnglish (US)
Pages (from-to)515-524
Number of pages10
JournalEssays in Biochemistry
Volume62
Issue number4
DOIs
StatePublished - Oct 26 2018

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Signal Transduction
Signal transduction
Communication
Control theory
Research
Signal processing
Molecules
Experiments

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Experimental and engineering approaches to intracellular communication. / Albeck, John; Pargett, Michael; Davies, Alexander E.

In: Essays in Biochemistry, Vol. 62, No. 4, 26.10.2018, p. 515-524.

Research output: Contribution to journalReview article

Albeck, John ; Pargett, Michael ; Davies, Alexander E. / Experimental and engineering approaches to intracellular communication. In: Essays in Biochemistry. 2018 ; Vol. 62, No. 4. pp. 515-524.
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