Experimental allergic neuritis in the SJL/J mouse: dysfunction of peripheral nerve without clinical signs

Michael E. Dieperink, Alison O'Neill, Ricardo A Maselli, Kari Stefansson

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8 Scopus citations

Abstract

Experimental allergic neuritis (EAN) was studied in the SJL/J mouse and compared to EAN in the Lewis rat. The Lewis rat developed hind limb weakness and weight loss while the SJL/J mouse had no discernible clinical abnormalities. The SJL/J mouse, however, suffered subclinical damage to peripheral nerve (PN) myelin. Both species reproducibly developed electrophysiologic dysfunction of PN and histopathology confined to the peripheral nervous system (PNS). Understanding of autoimmune demyelination in the central nervous system was greatly enhanced by the development of experimental allergic encephalomyelitis in the SJL/J mouse. We believe that EAN in the SJL/J mouse could lead to a similar increase in our understanding of autoimmune demyelination in the PNS.

Original languageEnglish (US)
Pages (from-to)247-259
Number of pages13
JournalJournal of Neuroimmunology
Volume35
Issue number1-3
DOIs
StatePublished - 1991
Externally publishedYes

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Keywords

  • Experimental allergic neuritis
  • Lewis rat
  • SJL/J mouse

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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