Experimental adenovirus hemorrhagic disease in white-tailed deer fawns

Leslie Woods, Howard D. Lehmkuhl, Pamela K. Swift, Philip H. Chiu, Richard S. Hanley, Robert W. Nordhausen, Michelle H. Stillian, Mark L. Drew

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Infection with a newly described endotheliotropic adenovirus was the cause of a 1993 epizootic reminiscent of hemorrhagic disease in California mule deer (Odocoileus hemionus columbianus and O. hemionus hemionus). Pulmonary edema and intestinal luminal hemorrhage, or necrotizing stomatitis associated with systemic or localized vasculitis, respectively, were common lesions seen in animals that died during the epizootic. In order to determine if white-tailed deer (Odocoileus virginianus) also are susceptible to infection and fatal disease with the deer adenovirus, eight white-tailed deer fawns (4-to 6-mo-old) were inoculated with purified deer adenovirus. Four were inoculated intravenously and four were inoculated through the mucous membranes. Seven days post-inoculation, one of the fawns inoculated intravenously died. Pulmonary edema and hemorrhagic enteropathy were associated with pulmonary and intestinal vasculitis with systemic multiorgan distribution of endotheliotropic adenovirus as demonstrated by transmission electron microscopy and immunohistochemistry. Adenovirus was reisolated from lung homogenates of the fawn that died of adenovirus hemorrhagic disease.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalJournal of Wildlife Diseases
Volume37
Issue number1
StatePublished - Jan 2001

Fingerprint

fawns
Deer
Adenoviridae
Odocoileus virginianus
deer
Atadenovirus
Odocoileus hemionus
Pulmonary Edema
lungs
vasculitis
Systemic Vasculitis
Lung
edema
Stomatitis
Equidae
Vasculitis
epizootic hemorrhagic disease
Infection
Transmission Electron Microscopy
Mucous Membrane

Keywords

  • Adenovirus
  • Experimental infection
  • Hemorrhagic disease
  • Hemorrhagic enteropathy
  • Odocolieus virginianus
  • Pulmonary edema
  • White-tailed deer

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Woods, L., Lehmkuhl, H. D., Swift, P. K., Chiu, P. H., Hanley, R. S., Nordhausen, R. W., ... Drew, M. L. (2001). Experimental adenovirus hemorrhagic disease in white-tailed deer fawns. Journal of Wildlife Diseases, 37(1), 153-158.

Experimental adenovirus hemorrhagic disease in white-tailed deer fawns. / Woods, Leslie; Lehmkuhl, Howard D.; Swift, Pamela K.; Chiu, Philip H.; Hanley, Richard S.; Nordhausen, Robert W.; Stillian, Michelle H.; Drew, Mark L.

In: Journal of Wildlife Diseases, Vol. 37, No. 1, 01.2001, p. 153-158.

Research output: Contribution to journalArticle

Woods, L, Lehmkuhl, HD, Swift, PK, Chiu, PH, Hanley, RS, Nordhausen, RW, Stillian, MH & Drew, ML 2001, 'Experimental adenovirus hemorrhagic disease in white-tailed deer fawns', Journal of Wildlife Diseases, vol. 37, no. 1, pp. 153-158.
Woods L, Lehmkuhl HD, Swift PK, Chiu PH, Hanley RS, Nordhausen RW et al. Experimental adenovirus hemorrhagic disease in white-tailed deer fawns. Journal of Wildlife Diseases. 2001 Jan;37(1):153-158.
Woods, Leslie ; Lehmkuhl, Howard D. ; Swift, Pamela K. ; Chiu, Philip H. ; Hanley, Richard S. ; Nordhausen, Robert W. ; Stillian, Michelle H. ; Drew, Mark L. / Experimental adenovirus hemorrhagic disease in white-tailed deer fawns. In: Journal of Wildlife Diseases. 2001 ; Vol. 37, No. 1. pp. 153-158.
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