Experiences with new generation vaccines against equine viral arteritis, West Nile disease and African horse sickness

Nigel J Maclachlan, Udeni B. Balasuriya, Nancy L. Davis, Martha Collier, Robert E. Johnston, Gregory L. Ferraro, Alan J. Guthrie

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Viral diseases constitute an ever growing threat to the horse industry worldwide because of the rapid movement of large numbers of horses for competition and breeding. A number of different types of vaccines are available for protective immunization of horses against viral diseases. Traditional inactivated and live-attenuated (modified live virus, MLV) virus vaccines remain popular and efficacious but recombinant vaccines are increasingly being developed and used, in part because of the perceived deficiencies of some existing products. New generation vaccines include MLVs with deletions and/or mutations of critical genes, subunit vaccines that incorporate immunogenic proteins (or portions thereof) or expression vectors that produce these proteins as immunogens, and DNA vaccines. New generation vaccines have been developed for several viral diseases of horses. We recently have developed an alphavirus replicon-vectored equine arteritis virus (EAV) vaccine, and evaluated a commercial canary pox virus-vectored vaccine for West Nile disease. The success of these new-generation vaccines has catalyzed efforts to develop improved vaccines for the prevention of African horse sickness, a disease of emerging global significance.

Original languageEnglish (US)
Pages (from-to)5577-5582
Number of pages6
JournalVaccine
Volume25
Issue number30 SPEC. ISS.
DOIs
StatePublished - Jul 26 2007
Externally publishedYes

Keywords

  • African horsesickness
  • Equine viral arteritis
  • Horse
  • Vaccines
  • West Nile

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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  • Cite this

    Maclachlan, N. J., Balasuriya, U. B., Davis, N. L., Collier, M., Johnston, R. E., Ferraro, G. L., & Guthrie, A. J. (2007). Experiences with new generation vaccines against equine viral arteritis, West Nile disease and African horse sickness. Vaccine, 25(30 SPEC. ISS.), 5577-5582. https://doi.org/10.1016/j.vaccine.2006.12.058