Expeditious syntheses of two carbohydrate-linked cisplatin analogs

Yongsheng Chen, Adam Janczuk, Xi Chen, Jianqiang Wang, Mohamad Ksebati, Peng George Wang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and α-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-α-Gal trisaccharide intermediate in the synthesis of α-Gal-cisplatin.

Original languageEnglish (US)
Pages (from-to)1043-1046
Number of pages4
JournalCarbohydrate Research
Volume337
Issue number11
DOIs
StatePublished - Jun 5 2002
Externally publishedYes

Keywords

  • Chemo-enzymatic synthesis
  • Cisplatin analog
  • Fusion enzyme

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry

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