Abstract
A transition metal-free, one-pot protocol has been developed for the synthesis of 11H-indolo[3,2-c]isoquinolin-5-amines via the atom economical annulation of ethyl (2-cyano-phenyl)carbamates and 2-cyanobenzyl bromides. This method proceeds via sequential N-alkylation and base-promoted cyclization. Optimization data, substrate scope, mechanistic insights, and photoluminescence properties are discussed.
Original language | English (US) |
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Pages (from-to) | 5429-5433 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue number | 40 |
DOIs | |
State | Published - Sep 30 2015 |
Keywords
- Domino process
- Indolo[3,2-c]isoquinoline
- One-pot
- Photoluminescence
- Tandem cyclization
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery