Abstract
A transition metal-free, one-pot protocol has been developed for the synthesis of 11H-indolo[3,2-c]isoquinolin-5-amines via the atom economical annulation of ethyl (2-cyano-phenyl)carbamates and 2-cyanobenzyl bromides. This method proceeds via sequential N-alkylation and base-promoted cyclization. Optimization data, substrate scope, mechanistic insights, and photoluminescence properties are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5429-5433 |
| Number of pages | 5 |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue number | 40 |
| DOIs | |
| State | Published - Sep 30 2015 |
Keywords
- Domino process
- Indolo[3,2-c]isoquinoline
- One-pot
- Photoluminescence
- Tandem cyclization
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Nguyen, H. H., Fettinger, J. C., Haddadin, M. J., & Kurth, M. J. (2015). Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-Alkylation/tandem cyclization. Tetrahedron Letters, 56(40), 5429-5433. https://doi.org/10.1016/j.tetlet.2015.08.006