Expansion of corticomedullary junction high-susceptibility region (cmj-hsr) with aging: A clue in the pathogenesis of alzheimer's Disease?

Tsutomu Nakada, Hitoshi Matsuzawa, Hironaka Igarashi, Ingrid Kwee

Research output: Contribution to journalArticle

2 Scopus citations


Background: Susceptibility-weighted imaging (SWI) microscopy on a 7.0T system demonstrated the corticomedullary junction (CMJ) to be a high-susceptibility region (HSR) in young normal subjects, suggesting that functional alteration of cortical microcirculation could be assessed with this imaging method. Methods: Focused microscopic studies were performed on the parietal association cortex in 74 normal volunteers (ages 20-79 years; 35 female, 39 male) using a SWI algorithm on a system constructed based on General Electric Signa LX (Waukesha, WI, USA), equipped with a 900-mm clear bore superconducting magnet operating at 7.0T. Results: There was a clear-cut reduction in the thickness of the normal-appearing cortex (cortex, R2= .5290, P < .001) and expansion of CMJ-HSR (R2= .6919, P < .001). The sum of cortex thickness and CMJ-HSR thickness was essentially constant, suggesting that the observed expansion of CMR-HSR with aging likely occurred within the cortical mantle. Conclusion: CMJ-HSR expands significantly as a function of aging. Since CMJ-HSR represents a functionally distinct area with relatively slow venous flow, the observed expansion is believed to reflect alteration in cerebral microcirculation with increased age, providing another clue for pathogenesis of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalJournal of Neuroimaging
Issue number4
StatePublished - Oct 2012
Externally publishedYes



  • 7.0T
  • Microscopy
  • MRI
  • SWI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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