Exosomes as agents of change in the cardiovascular system

A. J. Poe, Anne A Knowlton

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Exosomes have an evolving role in paracrine and autocrine signaling, which is enhanced because these lipid vesicles are quite stable and can deliver miRNA, DNA, protein and other molecules to cells throughout the body. Most cell types release exosomes, and exosomes are found in all biological fluids, making them accessible biomarkers. Significantly, exosomes can carry a biologically potent cargo, which can alter the phenotype of recipient cells. In the cardiovascular system exosomes have been primarily studied for their role in mediating the beneficial effects of mesenchymal stem cells after myocardial injury. Exosomes released by cardiac cells in disease states, such as myocardial ischemia, can potentially have important pathophysiologic effects on other cardiac cells as well as on distant organs.

Original languageEnglish (US)
Pages (from-to)40-50
Number of pages11
JournalJournal of Molecular and Cellular Cardiology
Volume111
DOIs
StatePublished - Oct 1 2017

Keywords

  • Biomarker
  • Cardiac injury
  • Cardioprotection
  • Exosome
  • Mesenchymal stem cell
  • Microvesicle

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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