Exogenous ifn-alpha administration reduces influenza a virus replication in the lower respiratory tract of rhesus macaques

Shannon R. Matzinger, Timothy D. Carroll, Linda Fritts, Michael B. McChesney, Chris J Miller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA and OAS in the airways. RM treated with IFN-alpha 24 hours prior to influenza virus challenge had significantly lower peak vRNA levels in the trachea compared to untreated animals. In addition to blunting viral replication, IFN-alpha treatment minimized the weight loss and spike in body temperature after influenza infection of RM. These results confirm the importance of IFN-alpha induced innate immune responses in the rapid control of influenza A virus replication in primates.

Original languageEnglish (US)
Article numbere29255
JournalPLoS One
Volume6
Issue number12
DOIs
StatePublished - Dec 29 2011

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Orthomyxoviridae
Virus Replication
virus replication
Macaca mulatta
Viruses
respiratory system
Respiratory System
Influenza A virus
Innate Immunity
trachea (vertebrates)
interferons
Trachea
Body Temperature
influenza
Interferons
Primates
Human Influenza
body temperature
Weight Loss
weight loss

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Exogenous ifn-alpha administration reduces influenza a virus replication in the lower respiratory tract of rhesus macaques. / Matzinger, Shannon R.; Carroll, Timothy D.; Fritts, Linda; McChesney, Michael B.; Miller, Chris J.

In: PLoS One, Vol. 6, No. 12, e29255, 29.12.2011.

Research output: Contribution to journalArticle

Matzinger, Shannon R. ; Carroll, Timothy D. ; Fritts, Linda ; McChesney, Michael B. ; Miller, Chris J. / Exogenous ifn-alpha administration reduces influenza a virus replication in the lower respiratory tract of rhesus macaques. In: PLoS One. 2011 ; Vol. 6, No. 12.
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