Exercise and Risk of cardiovascular events in women with nonmetastatic breast cancer

Lee W. Jones, Laurel A. Habel, Erin Weltzien, Adrienne Castillo, Dipti Gupta, Candyce H. Kroenke, Marilyn L. Kwan, Charles P. Quesenberry, Jessica Scott, Barbara Sternfeld, Anthony Yu, Lawrence H. Kushi, Bette J. Caan

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Purpose Cardiovascular disease (CVD) is a leading cause of death among women with nonmetastatic breast cancer. Whether exercise is associated with reductions in CVD risk in patients with breast cancer with an elevated CVD risk phenotype is not known. Methods Using a prospective design, women (n = 2,973; mean age, 57 years) diagnosed with nonmetastatic breast cancer participating in two registry-based, regional cohort studies, completed a questionnaire that assessed leisure-Time recreational physical activity (metabolic equivalent task [MET]-h/wk). The primary end point was the first occurrence of any of the following: new diagnosis of coronary artery disease, heart failure, valve abnormality, arrhythmia, stroke, or CVD death, occurring after study enrollment. Results Median follow-up was 8.6 years (range, 0.2 to 14.8 years). In multivariable analysis, the incidence of cardiovascular events decreased across increasing total MET-h/wk categories (Ptrend <.001). Compared with,2 MET-h/wk, the adjusted hazard ratio was 0.91 (95% CI, 0.76 to 1.09) for 2 to 10.9 MET-h/wk, 0.79 (95% CI, 0.66 to 0.96) for 11 to 24.5 MET-h/wk, and 0.65 (95% CI, 0.53 to 0.80) for 24.5 MET-h/wk. Similar trends were observed for the incidence of coronary artery disease and heart failure (P values,.05). Adherence to national exercise guidelines for adult patients with cancer (ie, 9 MET-h/wk) was associated with an adjusted 23% reduction in the risk of cardiovascular events in comparison with not meeting the guidelines (< 9 MET-h/wk; P < .001). The association with exercise did not differ according to age, CVD risk factors, menopausal status, or anticancer treatment. Conclusion Exercise is associated with substantial, graded reductions in the incidence of cardiovascular events in women with nonmetastatic breast cancer.

Original languageEnglish (US)
Pages (from-to)2743-2749
Number of pages7
JournalJournal of Clinical Oncology
Volume34
Issue number23
DOIs
StatePublished - Aug 10 2016
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Exercise and Risk of cardiovascular events in women with nonmetastatic breast cancer'. Together they form a unique fingerprint.

  • Cite this

    Jones, L. W., Habel, L. A., Weltzien, E., Castillo, A., Gupta, D., Kroenke, C. H., Kwan, M. L., Quesenberry, C. P., Scott, J., Sternfeld, B., Yu, A., Kushi, L. H., & Caan, B. J. (2016). Exercise and Risk of cardiovascular events in women with nonmetastatic breast cancer. Journal of Clinical Oncology, 34(23), 2743-2749. https://doi.org/10.1200/JCO.2015.65.6603