Abstract
Objective: The purpose of this study was to examine the extent to which executive cognitive dysfunction and frontally-mediated behavioral disturbances are associated with functional impairment in patients with mild-to-moderate Alzheimer disease (AD). Methods: Patients with AD (N = 45) completed the Mattis Dementia Rating Scale, and patients' caregivers completed the Frontal Systems Behavioral Inventory and a modified form of the Lawton and Brody Activities of Daily Living (ADLs) Questionnaire. Results: Multiple-regression analyses revealed that executive cognitive dysfunction and apathy scores accounted for 44% of the variance in instrumental activities of daily living; executive cognitive dysfunction alone explained 17% of the variance in instrumental ADLs, and apathy scores explained an additional 27%. Executive dysfunction and frontal-behavioral impairment explained 28% of the variance in basic ADLs (BADLs), and, after accounting for executive dysfunction, apathy was the only symptom found to explain additional unique variance in BADLs. Conclusion: These findings suggest that specific cognitive and behavioral symptoms are associated with functional impairment in patients with AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-221 |
| Number of pages | 8 |
| Journal | American Journal of Geriatric Psychiatry |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Executive dysfunction and apathy, predict functional impairment in Alzheimer disease. / Boyle, Patricia A.; Malloy, Paul F.; Salloway, Stephen; Cahn-Weiner, Deborah; Cohen, Ronald; Cummings, Jeffrey L.
In: American Journal of Geriatric Psychiatry, Vol. 11, No. 2, 01.01.2003, p. 214-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Executive dysfunction and apathy, predict functional impairment in Alzheimer disease
AU - Boyle, Patricia A.
AU - Malloy, Paul F.
AU - Salloway, Stephen
AU - Cahn-Weiner, Deborah
AU - Cohen, Ronald
AU - Cummings, Jeffrey L.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Objective: The purpose of this study was to examine the extent to which executive cognitive dysfunction and frontally-mediated behavioral disturbances are associated with functional impairment in patients with mild-to-moderate Alzheimer disease (AD). Methods: Patients with AD (N = 45) completed the Mattis Dementia Rating Scale, and patients' caregivers completed the Frontal Systems Behavioral Inventory and a modified form of the Lawton and Brody Activities of Daily Living (ADLs) Questionnaire. Results: Multiple-regression analyses revealed that executive cognitive dysfunction and apathy scores accounted for 44% of the variance in instrumental activities of daily living; executive cognitive dysfunction alone explained 17% of the variance in instrumental ADLs, and apathy scores explained an additional 27%. Executive dysfunction and frontal-behavioral impairment explained 28% of the variance in basic ADLs (BADLs), and, after accounting for executive dysfunction, apathy was the only symptom found to explain additional unique variance in BADLs. Conclusion: These findings suggest that specific cognitive and behavioral symptoms are associated with functional impairment in patients with AD.
AB - Objective: The purpose of this study was to examine the extent to which executive cognitive dysfunction and frontally-mediated behavioral disturbances are associated with functional impairment in patients with mild-to-moderate Alzheimer disease (AD). Methods: Patients with AD (N = 45) completed the Mattis Dementia Rating Scale, and patients' caregivers completed the Frontal Systems Behavioral Inventory and a modified form of the Lawton and Brody Activities of Daily Living (ADLs) Questionnaire. Results: Multiple-regression analyses revealed that executive cognitive dysfunction and apathy scores accounted for 44% of the variance in instrumental activities of daily living; executive cognitive dysfunction alone explained 17% of the variance in instrumental ADLs, and apathy scores explained an additional 27%. Executive dysfunction and frontal-behavioral impairment explained 28% of the variance in basic ADLs (BADLs), and, after accounting for executive dysfunction, apathy was the only symptom found to explain additional unique variance in BADLs. Conclusion: These findings suggest that specific cognitive and behavioral symptoms are associated with functional impairment in patients with AD.
UR - http://www.scopus.com/inward/record.url?scp=0037371473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037371473&partnerID=8YFLogxK
U2 - 10.1097/00019442-200303000-00012
DO - 10.1097/00019442-200303000-00012
M3 - Article
C2 - 12611751
AN - SCOPUS:0037371473
VL - 11
SP - 214
EP - 221
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
SN - 1064-7481
IS - 2
ER -