Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows

David J. Smith, Weilin L. Shelver, Ronald E. Baynes, Lisa A Tell, Ronette Gehring, Mengjie Li, Terry Dutko, J. W. Schroeder, Grant Herges, Jim E. Riviere

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Twenty lactating dairy cattle were intravenously infused with either lipopolysaccharide (LPS) (n = 10) or sterile saline (n = 10). Five cattle in each group received three doses of flunixin meglumine administered by either intravenous infusion or intramuscular injection at 24 h intervals. Milk, urine, and tissues were collected. Thirty-six hours after the last flunixin administration, milk from six cows contained 5-hydroxyflunixin (5OHF) levels greater than the milk tolerance of 2 ng/mL; by 48 h, milk from two cows, a saline and a LPS-treated animal, had violative milk concentrations of 5OHF. A single animal treated with LPS and intramuscular flunixin contained violative flunixin residues in liver. The ratio of urinary flunixin/5OHF was correlated (P < 0.01; R<sup>2</sup> = 0.946) with liver flunixin residues in LPS-treated animals, but not (P = 0.96; R<sup>2</sup> = 0.003) in cows treated with saline in lieu of LPS. Violative residues of flunixin in dairy cattle may be related to LPS inhibition of flunixin metabolism.

Original languageEnglish (US)
Pages (from-to)4893-4901
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume63
Issue number19
DOIs
StatePublished - May 20 2015

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flunixin
Dairies
lipopolysaccharides
Lipopolysaccharides
Labels
dairy cows
Tissue
Milk
milk
Animals
Liver
cows
dairy cattle
Enzyme inhibition
Intramuscular Injections
animals
liver
flunixin meglumine
tissues
Intravenous Infusions

Keywords

  • dairy
  • extra-label
  • flunixin
  • holstein
  • liver
  • metabolite ratio
  • milk
  • residue

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows. / Smith, David J.; Shelver, Weilin L.; Baynes, Ronald E.; Tell, Lisa A; Gehring, Ronette; Li, Mengjie; Dutko, Terry; Schroeder, J. W.; Herges, Grant; Riviere, Jim E.

In: Journal of Agricultural and Food Chemistry, Vol. 63, No. 19, 20.05.2015, p. 4893-4901.

Research output: Contribution to journalArticle

Smith, David J. ; Shelver, Weilin L. ; Baynes, Ronald E. ; Tell, Lisa A ; Gehring, Ronette ; Li, Mengjie ; Dutko, Terry ; Schroeder, J. W. ; Herges, Grant ; Riviere, Jim E. / Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows. In: Journal of Agricultural and Food Chemistry. 2015 ; Vol. 63, No. 19. pp. 4893-4901.
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