Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum

W. J. Lederer, J. R. Berlin, N. M. Cohen, R. W. Hadley, Donald M Bers, M. B. Cannell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.

Original languageEnglish (US)
Pages (from-to)190-206
Number of pages17
JournalAnnals of the New York Academy of Sciences
Volume588
DOIs
StatePublished - 1990

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Excitation Contraction Coupling
Sarcoplasmic Reticulum
Sodium
Calcium
Muscle
Myocardium
Electric potential
Contraction
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum. / Lederer, W. J.; Berlin, J. R.; Cohen, N. M.; Hadley, R. W.; Bers, Donald M; Cannell, M. B.

In: Annals of the New York Academy of Sciences, Vol. 588, 1990, p. 190-206.

Research output: Contribution to journalArticle

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