Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum

W. J. Lederer, J. R. Berlin, N. M. Cohen, R. W. Hadley, Donald M Bers, M. B. Cannell

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.

Original languageEnglish (US)
Pages (from-to)190-206
Number of pages17
JournalAnnals of the New York Academy of Sciences
Volume588
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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