Excess parathyroid hormone adversely affects lipid metabolism in chronic renal failure

Mohammad Akmal, Siddika E Karakas, Amin R. Soliman, Shaul G. Massry

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Hyperlipidemia is common in chronic renal failure (CRF), but the underlying mechanisms are not clearly defined. Certain data points toward a potential role for the state of secondary hyperparathyroidism of CRF in its pathogenesis. We examined the effects of parathyroid hormone (PTH) on lipid metabolism utilizing intravenous fat tolerance test (IVFTT) and post-heparin lipolytic activity in five normal dogs, in six animals with CRF and secondary hyperparathyroidism (NPX) and in six normocalcemic-thyroparathyroidectomized dogs (NPX-PTX) with comparable degree and duration of CRF. NPX dogs had fasting hypertriglyceridemia (82 + 6.0 mg/dl vs. 49 ± 2.7 mg/dl in normal dogs, P < 0.01), abnormal IVFTT, and reduced post-heparin plasma LPL activity (151 ± 10 vs. 275 ± 15 μmol fatty acids/ml/min in normal dogs, P < 0.01). The NPX-PTX dogs had normal fasting levels of serum triglycerides (42 ± 0.6 mg/dl), normal IVFTT, and normal post-heparin plasma LPL (317 ± 19 μmol fatty acids/ml/min) despite CRF. Post-heparin HL activity in plasma was not different between NPX and NPX-TPX dogs. The results show that excess blood levels of PTH and not other consequences of CRF are mainly responsible for the abnormalities in lipid metabolism. The data are consistent with the notion that excess PTH reduces post-heparin LPL activity in plasma, which in turn results in impaired lipid removal from the circulation and consequently hyperlipidemia.

Original languageEnglish (US)
Pages (from-to)854-858
Number of pages5
JournalKidney International
Volume37
Issue number3
StatePublished - Mar 1990
Externally publishedYes

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Parathyroid Hormone
Lipid Metabolism
Chronic Kidney Failure
Dogs
Heparin
Secondary Hyperparathyroidism
Fats
Hyperlipidemias
Fasting
Fatty Acids
Hypertriglyceridemia
Triglycerides
Lipids
Serum

ASJC Scopus subject areas

  • Nephrology

Cite this

Excess parathyroid hormone adversely affects lipid metabolism in chronic renal failure. / Akmal, Mohammad; Karakas, Siddika E; Soliman, Amin R.; Massry, Shaul G.

In: Kidney International, Vol. 37, No. 3, 03.1990, p. 854-858.

Research output: Contribution to journalArticle

Akmal, Mohammad ; Karakas, Siddika E ; Soliman, Amin R. ; Massry, Shaul G. / Excess parathyroid hormone adversely affects lipid metabolism in chronic renal failure. In: Kidney International. 1990 ; Vol. 37, No. 3. pp. 854-858.
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