Examination of psychological risk factors for chronic pain following cardiac surgery

protocol for a prospective observational study

Michael H. McGillion, Shaunattonie Henry, Jason W. Busse, Carley Ouellette, Joel Katz, Manon Choinière, Andre Lamy, Richard Whitlock, Shirley Pettit, Jacqueline Hare, Krysten Gregus, Katheryn Brady, Nazari Dvirnik, Stephen Su Yang, Joel Parlow, Deborah Dumerton-Shore, Ian Gilron, D. Norman Buckley, Harsha Shanthanna, Sandra L. Carroll & 15 others Peter C. Coyte, Shanil Ebrahim, Wanrudee Isaranuwatchai, Denise N. Guerriere, Jeffrey S Hoch, James Khan, Joy MacDermid, Geraldine Martorella, J. Charles Victor, Judy Watt-Watson, Kimberly Howard-Quijano, Aman Mahajan, Matthew T.V. Chan, Hance Clarke, P. J. Devereaux

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Approximately 400 000 Americans and 36 000 Canadians undergo cardiac surgery annually, and up to 56% will develop chronic postsurgical pain (CPSP). The primary aim of this study is to explore the association of pain-related beliefs and gender-based pain expectations on the development of CPSP. Secondary goals are to: (A) explore risk factors for poor functional status and patient-level cost of illness from a societal perspective up to 12 months following cardiac surgery; and (B) determine the impact of CPSP on quality-adjusted life years (QALYs) borne by cardiac surgery, in addition to the incremental cost for one additional QALY gained, among those who develop CPSP compared with those who do not. METHODS AND ANALYSES: In this prospective cohort study, 1250 adults undergoing cardiac surgery, including coronary artery bypass grafting and open-heart procedures, will be recruited over a 3-year period. Putative risk factors for CPSP will be captured prior to surgery, at postoperative day 3 (in hospital) and day 30 (at home). Outcome data will be collected via telephone interview at 6-month and 12-month follow-up. We will employ generalised estimating equations to model the primary (CPSP) and secondary outcomes (function and cost) while adjusting for prespecified model covariates. QALYs will be estimated by converting data from the Short Form-12 (version 2) to a utility score. ETHICS AND DISSEMINATION: This protocol has been approved by the responsible bodies at each of the hospital sites, and study enrolment began May 2015. We will disseminate our results through CardiacPain.Net, a web-based knowledge dissemination platform, presentation at international conferences and publications in scientific journals. TRIAL REGISTRATION NUMBER: NCT01842568.

Original languageEnglish (US)
Pages (from-to)e022995
JournalBMJ open
Volume9
Issue number2
DOIs
StatePublished - Mar 1 2019

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Chronic Pain
Thoracic Surgery
Observational Studies
Prospective Studies
Psychology
Quality-Adjusted Life Years
Costs and Cost Analysis
Pain
Cost of Illness
Coronary Artery Bypass
Publications
Cohort Studies
Interviews

Keywords

  • cardiac surgery
  • health economics
  • pain management

ASJC Scopus subject areas

  • Medicine(all)

Cite this

McGillion, M. H., Henry, S., Busse, J. W., Ouellette, C., Katz, J., Choinière, M., ... Devereaux, P. J. (2019). Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study. BMJ open, 9(2), e022995. https://doi.org/10.1136/bmjopen-2018-022995

Examination of psychological risk factors for chronic pain following cardiac surgery : protocol for a prospective observational study. / McGillion, Michael H.; Henry, Shaunattonie; Busse, Jason W.; Ouellette, Carley; Katz, Joel; Choinière, Manon; Lamy, Andre; Whitlock, Richard; Pettit, Shirley; Hare, Jacqueline; Gregus, Krysten; Brady, Katheryn; Dvirnik, Nazari; Yang, Stephen Su; Parlow, Joel; Dumerton-Shore, Deborah; Gilron, Ian; Buckley, D. Norman; Shanthanna, Harsha; Carroll, Sandra L.; Coyte, Peter C.; Ebrahim, Shanil; Isaranuwatchai, Wanrudee; Guerriere, Denise N.; Hoch, Jeffrey S; Khan, James; MacDermid, Joy; Martorella, Geraldine; Victor, J. Charles; Watt-Watson, Judy; Howard-Quijano, Kimberly; Mahajan, Aman; Chan, Matthew T.V.; Clarke, Hance; Devereaux, P. J.

In: BMJ open, Vol. 9, No. 2, 01.03.2019, p. e022995.

Research output: Contribution to journalArticle

McGillion, MH, Henry, S, Busse, JW, Ouellette, C, Katz, J, Choinière, M, Lamy, A, Whitlock, R, Pettit, S, Hare, J, Gregus, K, Brady, K, Dvirnik, N, Yang, SS, Parlow, J, Dumerton-Shore, D, Gilron, I, Buckley, DN, Shanthanna, H, Carroll, SL, Coyte, PC, Ebrahim, S, Isaranuwatchai, W, Guerriere, DN, Hoch, JS, Khan, J, MacDermid, J, Martorella, G, Victor, JC, Watt-Watson, J, Howard-Quijano, K, Mahajan, A, Chan, MTV, Clarke, H & Devereaux, PJ 2019, 'Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study', BMJ open, vol. 9, no. 2, pp. e022995. https://doi.org/10.1136/bmjopen-2018-022995
McGillion, Michael H. ; Henry, Shaunattonie ; Busse, Jason W. ; Ouellette, Carley ; Katz, Joel ; Choinière, Manon ; Lamy, Andre ; Whitlock, Richard ; Pettit, Shirley ; Hare, Jacqueline ; Gregus, Krysten ; Brady, Katheryn ; Dvirnik, Nazari ; Yang, Stephen Su ; Parlow, Joel ; Dumerton-Shore, Deborah ; Gilron, Ian ; Buckley, D. Norman ; Shanthanna, Harsha ; Carroll, Sandra L. ; Coyte, Peter C. ; Ebrahim, Shanil ; Isaranuwatchai, Wanrudee ; Guerriere, Denise N. ; Hoch, Jeffrey S ; Khan, James ; MacDermid, Joy ; Martorella, Geraldine ; Victor, J. Charles ; Watt-Watson, Judy ; Howard-Quijano, Kimberly ; Mahajan, Aman ; Chan, Matthew T.V. ; Clarke, Hance ; Devereaux, P. J. / Examination of psychological risk factors for chronic pain following cardiac surgery : protocol for a prospective observational study. In: BMJ open. 2019 ; Vol. 9, No. 2. pp. e022995.
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AU - McGillion, Michael H.

AU - Henry, Shaunattonie

AU - Busse, Jason W.

AU - Ouellette, Carley

AU - Katz, Joel

AU - Choinière, Manon

AU - Lamy, Andre

AU - Whitlock, Richard

AU - Pettit, Shirley

AU - Hare, Jacqueline

AU - Gregus, Krysten

AU - Brady, Katheryn

AU - Dvirnik, Nazari

AU - Yang, Stephen Su

AU - Parlow, Joel

AU - Dumerton-Shore, Deborah

AU - Gilron, Ian

AU - Buckley, D. Norman

AU - Shanthanna, Harsha

AU - Carroll, Sandra L.

AU - Coyte, Peter C.

AU - Ebrahim, Shanil

AU - Isaranuwatchai, Wanrudee

AU - Guerriere, Denise N.

AU - Hoch, Jeffrey S

AU - Khan, James

AU - MacDermid, Joy

AU - Martorella, Geraldine

AU - Victor, J. Charles

AU - Watt-Watson, Judy

AU - Howard-Quijano, Kimberly

AU - Mahajan, Aman

AU - Chan, Matthew T.V.

AU - Clarke, Hance

AU - Devereaux, P. J.

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N2 - INTRODUCTION: Approximately 400 000 Americans and 36 000 Canadians undergo cardiac surgery annually, and up to 56% will develop chronic postsurgical pain (CPSP). The primary aim of this study is to explore the association of pain-related beliefs and gender-based pain expectations on the development of CPSP. Secondary goals are to: (A) explore risk factors for poor functional status and patient-level cost of illness from a societal perspective up to 12 months following cardiac surgery; and (B) determine the impact of CPSP on quality-adjusted life years (QALYs) borne by cardiac surgery, in addition to the incremental cost for one additional QALY gained, among those who develop CPSP compared with those who do not. METHODS AND ANALYSES: In this prospective cohort study, 1250 adults undergoing cardiac surgery, including coronary artery bypass grafting and open-heart procedures, will be recruited over a 3-year period. Putative risk factors for CPSP will be captured prior to surgery, at postoperative day 3 (in hospital) and day 30 (at home). Outcome data will be collected via telephone interview at 6-month and 12-month follow-up. We will employ generalised estimating equations to model the primary (CPSP) and secondary outcomes (function and cost) while adjusting for prespecified model covariates. QALYs will be estimated by converting data from the Short Form-12 (version 2) to a utility score. ETHICS AND DISSEMINATION: This protocol has been approved by the responsible bodies at each of the hospital sites, and study enrolment began May 2015. We will disseminate our results through CardiacPain.Net, a web-based knowledge dissemination platform, presentation at international conferences and publications in scientific journals. TRIAL REGISTRATION NUMBER: NCT01842568.

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