Examination of fluconazole-induced alopecia in an animal model and human cohort

George R. Thompson, Charles R. Krois, Verena K. Affolter, Angela D. Everett, E. Katarina Varjonen, Victoria Sharon, Anil Singapuri, Michael Dennis, Ian McHardy, Hong Sik Yoo, Dawn M. Fedor, Nathan P. Wiederhold, Phylicia A. Aaron, Angie Gelli, Joseph L. Napoli, Stephen D. White

Research output: Contribution to journalArticle

Abstract

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

Original languageEnglish (US)
Article numbere01384-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • Alopecia
  • Antifungal
  • Fluconazole
  • Side effect

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Thompson, G. R., Krois, C. R., Affolter, V. K., Everett, A. D., Katarina Varjonen, E., Sharon, V., Singapuri, A., Dennis, M., McHardy, I., Yoo, H. S., Fedor, D. M., Wiederhold, N. P., Aaron, P. A., Gelli, A., Napoli, J. L., & White, S. D. (2019). Examination of fluconazole-induced alopecia in an animal model and human cohort. Antimicrobial Agents and Chemotherapy, 63(2), [e01384-18]. https://doi.org/10.1128/AAC.01384-18