Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers

Angela M. Hughes, Danika L Bannasch, Kristin Kellett, Anita M. Oberbauer

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Inherited hypoadrenocorticism occurs in some dog breeds including the Nova Scotia Duck Tolling Retriever (NSDTR) and is thought to be due to an immune attack on the adrenal glands. The genetic cause of this disorder in dogs has not been identified; however, many genes have been associated with hypoadrenocorticism and other immune-mediated conditions in humans including AIRE, BAFF, Casp10, CD28, CTLA-4, FASL, PTPN22, and TNFRSF6B. Microsatellite marker loci were analysed for linkage with the disease phenotype in a pedigree of NSDTRs and excluded all genes examined, the exception being CTLA-4, which was neither excluded nor shown to be associated by this analysis. Thus, genes associated with hypoadrenocorticism in humans were not linked with the condition in the dog. Further examination is necessary to identify the genetic cause of inherited hypoadrenocorticism in dogs and this may reveal a novel gene not yet implicated with immune-mediated disease.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalVeterinary Journal
Volume187
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • Addison's disease
  • Candidate gene
  • Hypoadrenocorticism
  • Immune-mediated
  • Nova Scotia Duck Tolling Retriever

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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