Exacerbation of Pneumocystis carinii pneumonia in immunodeficient (scid) mice by concurrent infection with a pneumovirus

M. V. Bray, Stephen W Barthold, C. L. Sidman, J. Roths, A. L. Smith

Research output: Contribution to journalArticle

11 Scopus citations


scid mice naturally infected with Pneumocystis carinii and inoculated with a normally apathogenic pneumovirus had significantly higher P. carinii cyst counts and developed significantly more severe P. carinii-related disease than did sham-inoculated, P. carinii-infected scid mice. P. carinii-free, virus-infected scid mice survived for 2 months despite high pulmonary virus titers. These results show that a respiratory virus infection can exacerbate P. carinii disease in an immunocompromised-rodent model.

Original languageEnglish (US)
Pages (from-to)1586-1588
Number of pages3
JournalInfection and Immunity
Issue number4
StatePublished - 1993
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

Cite this