Exacerbation of Lyme arthritis in beige mice

Stephen W Barthold, M. De Souza

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Borrelia burgdorferi-induced disease susceptibility was explored in disease-resistant C57/BL6 (B6) and -susceptible C3H/He (C3H) mice with and without the beige (bg) mutation, which is associated with granulocyte and NK cell dysfunction. Both B6 and C3H mice had more prevalent and severe arthritis than their congenic partners, and B6-bg mice developed arthritis equal in severity to that in C3H mice. Spirochetes were visualized in joint tissue of B6-bg mice but not B6 mice. No differences in spirochete isolation from tissues or immunoglobulin titers to B. burgdorferi were noted between groups. Depletion of granulocytes with cyclophosphamide and macrophages with silica in B6 and C3H mice modified arthritis susceptibility, but depletion of NK cells by serotherapy in B6 mice had no effect on disease. This study demonstrates that innate genetic resistance to Lyme arthritis in mice can be overcome by a single gene mutation, which is probably mediated through granulocyte function.

Original languageEnglish (US)
Pages (from-to)778-784
Number of pages7
JournalJournal of Infectious Diseases
Volume172
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Lyme Disease
Inbred C3H Mouse
Granulocytes
Arthritis
Spirochaetales
Borrelia burgdorferi
Natural Killer Cells
Mutation
Passive Immunization
Disease Susceptibility
Silicon Dioxide
Cyclophosphamide
Immunoglobulins
Joints
Macrophages
Genes

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Exacerbation of Lyme arthritis in beige mice. / Barthold, Stephen W; De Souza, M.

In: Journal of Infectious Diseases, Vol. 172, No. 3, 1995, p. 778-784.

Research output: Contribution to journalArticle

Barthold, Stephen W ; De Souza, M. / Exacerbation of Lyme arthritis in beige mice. In: Journal of Infectious Diseases. 1995 ; Vol. 172, No. 3. pp. 778-784.
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