Ex vivo synthesis of articular cartilage

R. G. Lebaron, K. A. Athanasiou

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


This review discusses modern methods used for the synthesis of articular cartilage ex vivo. The value of culturing articular chondrocytes as a monolayer and in three-dimensional lattices is discussed. Of particular interest are techniques involving seeding of chondrocytes onto synthetic, biodegradable, polymeric scaffolds, and natural materials, such as collagen and agarose. Also discussed is the use of bioreactors to modulate the fluid-flow-induced shear environment of cell-seeded scaffolds. Biodegradable scaffolds are central to the efforts to tissue engineer articular cartilage ex vivo. A review of salient efforts to design and use such scaffolds is presented, along with our thoughts on potential future improvements. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)2575-2587
Number of pages13
Issue number24
StatePublished - Dec 15 2000
Externally publishedYes


  • Articular cartilage repair
  • Biodegradable scaffolds
  • Bioreactors
  • Chondrocytes
  • Peptides
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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