Ex vivo synthesis of articular cartilage

R. G. Lebaron, K. A. Athanasiou

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

This review discusses modern methods used for the synthesis of articular cartilage ex vivo. The value of culturing articular chondrocytes as a monolayer and in three-dimensional lattices is discussed. Of particular interest are techniques involving seeding of chondrocytes onto synthetic, biodegradable, polymeric scaffolds, and natural materials, such as collagen and agarose. Also discussed is the use of bioreactors to modulate the fluid-flow-induced shear environment of cell-seeded scaffolds. Biodegradable scaffolds are central to the efforts to tissue engineer articular cartilage ex vivo. A review of salient efforts to design and use such scaffolds is presented, along with our thoughts on potential future improvements. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)2575-2587
Number of pages13
JournalBiomaterials
Volume21
Issue number24
StatePublished - Dec 15 2000
Externally publishedYes

Fingerprint

Cartilage
Articular Cartilage
Chondrocytes
Scaffolds
Bioreactors
Sepharose
Collagen
Joints
Scaffolds (biology)
Flow of fluids
Monolayers
Tissue
Engineers

Keywords

  • Articular cartilage repair
  • Biodegradable scaffolds
  • Bioreactors
  • Chondrocytes
  • Peptides
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Lebaron, R. G., & Athanasiou, K. A. (2000). Ex vivo synthesis of articular cartilage. Biomaterials, 21(24), 2575-2587.

Ex vivo synthesis of articular cartilage. / Lebaron, R. G.; Athanasiou, K. A.

In: Biomaterials, Vol. 21, No. 24, 15.12.2000, p. 2575-2587.

Research output: Contribution to journalArticle

Lebaron, RG & Athanasiou, KA 2000, 'Ex vivo synthesis of articular cartilage', Biomaterials, vol. 21, no. 24, pp. 2575-2587.
Lebaron RG, Athanasiou KA. Ex vivo synthesis of articular cartilage. Biomaterials. 2000 Dec 15;21(24):2575-2587.
Lebaron, R. G. ; Athanasiou, K. A. / Ex vivo synthesis of articular cartilage. In: Biomaterials. 2000 ; Vol. 21, No. 24. pp. 2575-2587.
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