Evolving epidemiologic trends in nonclear cell renal cell cancer: An analysis of the California cancer registry

Ashok Pai, Ann Brunson, Monica Brown, Chong-Xian Pan, Primo N Lara

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Abstract

Objective To evaluate the California Cancer Registry in order to define nonclear cell renal cell cancer (RCC) clinical features and outcomes, identify prognostic variables, and generate hypotheses for further study. Methods Patients with invasive RCC tumors in the California Cancer Registry from 1998 to 2009 (n = 38,251) were analyzed, of which 4483 (11.7%) were of the nonclear cell type. Baseline clinical demographics and tumor characteristics were collected. Primary outcome measures were 3-year cause-specific survival (CSS) and overall survival (OS). Results Of 4483 nonclear cell RCC cases, 3304 (73.7%) were diagnosed between 2004 and 2009. Histologic distribution was as follows: papillary 63.9%, chromophobe 33.6%, and "other" 2.5% (including medullary and collecting duct tumors). Univariate analysis showed that chromophobe histology, female sex, and higher socioeconomic status were associated with significantly better OS and CSS. Patients in the later era (2004-2009) appeared to have better OS. Multivariate analysis showed the following to be independently associated with outcomes (hazard ratios shown for CSS and OS, respectively): chromophobe (0.48, 0.56; P <.001), medullary/collecting duct (2.99, 2.42; P <.001), no nephrectomy (2.84, 3.18; P <.001), regional stage (5.84, 1.98; P <.001), distant stage (25.7, 7.67; P <.001), and non-Hispanic blacks (1.5, P =.006; 1.25, P =.03). Conclusion This large registry analysis demonstrated emerging epidemiologic trends in this uncommon RCC subset. Clinical variables associated with CSS and OS were identified that can potentially inform the design of future clinical trials in nonclear cell RCC.

Original languageEnglish (US)
Pages (from-to)840-845
Number of pages6
JournalUrology
Volume82
Issue number4
DOIs
StatePublished - Oct 2013

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Renal Cell Carcinoma
Registries
Survival
Neoplasms
Nephrectomy
Social Class
Histology
Multivariate Analysis
Demography
Outcome Assessment (Health Care)
Clinical Trials

ASJC Scopus subject areas

  • Urology

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Evolving epidemiologic trends in nonclear cell renal cell cancer : An analysis of the California cancer registry. / Pai, Ashok; Brunson, Ann; Brown, Monica; Pan, Chong-Xian; Lara, Primo N.

In: Urology, Vol. 82, No. 4, 10.2013, p. 840-845.

Research output: Contribution to journalArticle

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title = "Evolving epidemiologic trends in nonclear cell renal cell cancer: An analysis of the California cancer registry",
abstract = "Objective To evaluate the California Cancer Registry in order to define nonclear cell renal cell cancer (RCC) clinical features and outcomes, identify prognostic variables, and generate hypotheses for further study. Methods Patients with invasive RCC tumors in the California Cancer Registry from 1998 to 2009 (n = 38,251) were analyzed, of which 4483 (11.7{\%}) were of the nonclear cell type. Baseline clinical demographics and tumor characteristics were collected. Primary outcome measures were 3-year cause-specific survival (CSS) and overall survival (OS). Results Of 4483 nonclear cell RCC cases, 3304 (73.7{\%}) were diagnosed between 2004 and 2009. Histologic distribution was as follows: papillary 63.9{\%}, chromophobe 33.6{\%}, and {"}other{"} 2.5{\%} (including medullary and collecting duct tumors). Univariate analysis showed that chromophobe histology, female sex, and higher socioeconomic status were associated with significantly better OS and CSS. Patients in the later era (2004-2009) appeared to have better OS. Multivariate analysis showed the following to be independently associated with outcomes (hazard ratios shown for CSS and OS, respectively): chromophobe (0.48, 0.56; P <.001), medullary/collecting duct (2.99, 2.42; P <.001), no nephrectomy (2.84, 3.18; P <.001), regional stage (5.84, 1.98; P <.001), distant stage (25.7, 7.67; P <.001), and non-Hispanic blacks (1.5, P =.006; 1.25, P =.03). Conclusion This large registry analysis demonstrated emerging epidemiologic trends in this uncommon RCC subset. Clinical variables associated with CSS and OS were identified that can potentially inform the design of future clinical trials in nonclear cell RCC.",
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T1 - Evolving epidemiologic trends in nonclear cell renal cell cancer

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N2 - Objective To evaluate the California Cancer Registry in order to define nonclear cell renal cell cancer (RCC) clinical features and outcomes, identify prognostic variables, and generate hypotheses for further study. Methods Patients with invasive RCC tumors in the California Cancer Registry from 1998 to 2009 (n = 38,251) were analyzed, of which 4483 (11.7%) were of the nonclear cell type. Baseline clinical demographics and tumor characteristics were collected. Primary outcome measures were 3-year cause-specific survival (CSS) and overall survival (OS). Results Of 4483 nonclear cell RCC cases, 3304 (73.7%) were diagnosed between 2004 and 2009. Histologic distribution was as follows: papillary 63.9%, chromophobe 33.6%, and "other" 2.5% (including medullary and collecting duct tumors). Univariate analysis showed that chromophobe histology, female sex, and higher socioeconomic status were associated with significantly better OS and CSS. Patients in the later era (2004-2009) appeared to have better OS. Multivariate analysis showed the following to be independently associated with outcomes (hazard ratios shown for CSS and OS, respectively): chromophobe (0.48, 0.56; P <.001), medullary/collecting duct (2.99, 2.42; P <.001), no nephrectomy (2.84, 3.18; P <.001), regional stage (5.84, 1.98; P <.001), distant stage (25.7, 7.67; P <.001), and non-Hispanic blacks (1.5, P =.006; 1.25, P =.03). Conclusion This large registry analysis demonstrated emerging epidemiologic trends in this uncommon RCC subset. Clinical variables associated with CSS and OS were identified that can potentially inform the design of future clinical trials in nonclear cell RCC.

AB - Objective To evaluate the California Cancer Registry in order to define nonclear cell renal cell cancer (RCC) clinical features and outcomes, identify prognostic variables, and generate hypotheses for further study. Methods Patients with invasive RCC tumors in the California Cancer Registry from 1998 to 2009 (n = 38,251) were analyzed, of which 4483 (11.7%) were of the nonclear cell type. Baseline clinical demographics and tumor characteristics were collected. Primary outcome measures were 3-year cause-specific survival (CSS) and overall survival (OS). Results Of 4483 nonclear cell RCC cases, 3304 (73.7%) were diagnosed between 2004 and 2009. Histologic distribution was as follows: papillary 63.9%, chromophobe 33.6%, and "other" 2.5% (including medullary and collecting duct tumors). Univariate analysis showed that chromophobe histology, female sex, and higher socioeconomic status were associated with significantly better OS and CSS. Patients in the later era (2004-2009) appeared to have better OS. Multivariate analysis showed the following to be independently associated with outcomes (hazard ratios shown for CSS and OS, respectively): chromophobe (0.48, 0.56; P <.001), medullary/collecting duct (2.99, 2.42; P <.001), no nephrectomy (2.84, 3.18; P <.001), regional stage (5.84, 1.98; P <.001), distant stage (25.7, 7.67; P <.001), and non-Hispanic blacks (1.5, P =.006; 1.25, P =.03). Conclusion This large registry analysis demonstrated emerging epidemiologic trends in this uncommon RCC subset. Clinical variables associated with CSS and OS were identified that can potentially inform the design of future clinical trials in nonclear cell RCC.

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