Evolution of the SNF2 family of proteins: Subfamilies with distinct sequences and functions

Jonathan A Eisen, Kevin S. Sweder, Philip C. Hanawalt

Research output: Contribution to journalArticlepeer-review

607 Scopus citations


The SNF2 family of proteins includes representatives from a variety of species with roles In cellular processes such as transcrlptional regulation (e.g. M0T1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g. lodestar) and various aspects of processing of DNA damage, including nucleotide excision repair (e.g. RAD16 and ERCC6), recombinational pathways (e.g. RAD54) and post-replication daughter strand gap repair (e.g. RAD5). This family also includes many proteins with no known function. To better characterize this family of proteins we have used molecular phylogenetic techniques to infer evolutionary relationships among the family members. We have divided the SNF2 family Into multiple subfamilies, each of which represents what we propose to be a functionally and evolutionary distinct group. We have then used the subfamily structure to predict the functions of some of the uncharacterized proteins in the SNF2 family. We discuss possible implications of this evolutionary analysis on the general properties and evolution of the SNF2 family.

Original languageEnglish (US)
Pages (from-to)2715-2723
Number of pages9
JournalNucleic Acids Research
Issue number14
StatePublished - Jul 25 1995
Externally publishedYes

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics


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