Abstract
Many Proteobacteria use the chaperonelusher pathway to assemble proteinaceous filaments on the bacterial surface. These filaments can curl intofimbrial or nonfimbrial surface structures (e.g., a capsule or spore coat). This article reviews the phylogeny of operons belonging to the chaperonelusher assembly class to explore the utility of establishing a scheme for subdividing them into clades of phylogenetically related gene clusters. Based on usher amino acid sequence comparisons, our analysis shows that the chaperonelusher assembly class is subdivided into six major phylogenetic clades, which we have termed α-, β-, γ-, κ-, π-, and σ-fimbriae. Members of each clade share related operon structures and encode fimbrial subunits with similar protein domains. The proposed classification system offers a simple and convenient method for assigning newly discovered chaperonelusher systems to one of the six major phylogenetic groups.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 551-575 |
| Number of pages | 25 |
| Journal | Microbiology and Molecular Biology Reviews |
| Volume | 71 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2007 |
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ASJC Scopus subject areas
- Molecular Biology
- Microbiology
- Genetics
Cite this
Evolution of the chaperone/usher assembly pathway : Fimbrial classification goes Greek. / Nuccio, Sean Paul; Baumler, Andreas J.
In: Microbiology and Molecular Biology Reviews, Vol. 71, No. 4, 12.2007, p. 551-575.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evolution of the chaperone/usher assembly pathway
T2 - Fimbrial classification goes Greek
AU - Nuccio, Sean Paul
AU - Baumler, Andreas J
PY - 2007/12
Y1 - 2007/12
N2 - Many Proteobacteria use the chaperonelusher pathway to assemble proteinaceous filaments on the bacterial surface. These filaments can curl intofimbrial or nonfimbrial surface structures (e.g., a capsule or spore coat). This article reviews the phylogeny of operons belonging to the chaperonelusher assembly class to explore the utility of establishing a scheme for subdividing them into clades of phylogenetically related gene clusters. Based on usher amino acid sequence comparisons, our analysis shows that the chaperonelusher assembly class is subdivided into six major phylogenetic clades, which we have termed α-, β-, γ-, κ-, π-, and σ-fimbriae. Members of each clade share related operon structures and encode fimbrial subunits with similar protein domains. The proposed classification system offers a simple and convenient method for assigning newly discovered chaperonelusher systems to one of the six major phylogenetic groups.
AB - Many Proteobacteria use the chaperonelusher pathway to assemble proteinaceous filaments on the bacterial surface. These filaments can curl intofimbrial or nonfimbrial surface structures (e.g., a capsule or spore coat). This article reviews the phylogeny of operons belonging to the chaperonelusher assembly class to explore the utility of establishing a scheme for subdividing them into clades of phylogenetically related gene clusters. Based on usher amino acid sequence comparisons, our analysis shows that the chaperonelusher assembly class is subdivided into six major phylogenetic clades, which we have termed α-, β-, γ-, κ-, π-, and σ-fimbriae. Members of each clade share related operon structures and encode fimbrial subunits with similar protein domains. The proposed classification system offers a simple and convenient method for assigning newly discovered chaperonelusher systems to one of the six major phylogenetic groups.
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UR - http://www.scopus.com/inward/citedby.url?scp=37349093031&partnerID=8YFLogxK
U2 - 10.1128/MMBR.00014-07
DO - 10.1128/MMBR.00014-07
M3 - Article
C2 - 18063717
AN - SCOPUS:37349093031
VL - 71
SP - 551
EP - 575
JO - Microbiology and Molecular Biology Reviews
JF - Microbiology and Molecular Biology Reviews
SN - 1092-2172
IS - 4
ER -