Evolution of obstructive sleep apnea in infants with cleft palate and micrognathia

Christopher M. Cielo, Jesse A. Taylor, Arastoo Vossough, Jerilynn Radcliffe, Allison Thomas, Ruth Bradford, Janet Lioy, Ignacio E. Tapia, Reza Assadsangabi, Justine Shults, Carole L. Marcus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Study Objectives: Children with craniofacial anomalies are a heterogeneous group at high risk for obstructive sleep apnea (OSA). However, the prevalence and structural predictors of OSA in this population are unknown. We hypothesized that infants with micrognathia would have more significant OSA than those with isolated cleft palate ± cleft lip (ICP), and those with ICP would have more significant OSA than controls. We postulated that OSA severity would correlate with reduced mandibular size, neurodevelopmental scores, and growth. Methods: Prospective cohort study. 15 infants with ICP, 19 with micrognathia, and 9 controls were recruited for polysomnograms, neurodevelopmental testing, cephalometrics (ICP and micrognathia groups) at baseline and a follow-up at 6 mo. Results: Baseline apnea-hypopnea index (AHI) [median (range)] of the micrognathia group [20.1 events/h (0.8, 54.7)] was greater than ICP [3.2 (0.3, 30.7)] or controls [3.1 (0.5, 23.3)] (p = 0.001). Polysomnographic findings were similar between ICP and controls. Controls had a greater AHI than previously reported in the literature. Cephalometric measures of both midface hypoplasia and micrognathia correlated with OSA severity. Neurodevelopment was similar among groups. OSA improved with growth in participants with ICP and postoperatively in infants with micrognathia. Conclusions: Micrognathia, but not ICP, was associated with more significant OSA compared to controls. Both midface and mandibular hypoplasia contribute to OSA in these populations. OSA improved after surgical correction in most infants with micrognathia, and improved without intervention before palate repair in infants with ICP.

Original languageEnglish (US)
Pages (from-to)979-987
Number of pages9
JournalJournal of Clinical Sleep Medicine
Volume12
Issue number7
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Micrognathism
Cleft Palate
Obstructive Sleep Apnea
Cephalometry
Apnea
Palate
Cleft Lip
Growth

Keywords

  • Cleft palate
  • Craniofacial
  • Infant
  • Micrognathia
  • Obstructive sleep apnea
  • Pediatrics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

Cielo, C. M., Taylor, J. A., Vossough, A., Radcliffe, J., Thomas, A., Bradford, R., ... Marcus, C. L. (2016). Evolution of obstructive sleep apnea in infants with cleft palate and micrognathia. Journal of Clinical Sleep Medicine, 12(7), 979-987. https://doi.org/10.5664/jcsm.5930

Evolution of obstructive sleep apnea in infants with cleft palate and micrognathia. / Cielo, Christopher M.; Taylor, Jesse A.; Vossough, Arastoo; Radcliffe, Jerilynn; Thomas, Allison; Bradford, Ruth; Lioy, Janet; Tapia, Ignacio E.; Assadsangabi, Reza; Shults, Justine; Marcus, Carole L.

In: Journal of Clinical Sleep Medicine, Vol. 12, No. 7, 01.01.2016, p. 979-987.

Research output: Contribution to journalArticle

Cielo, CM, Taylor, JA, Vossough, A, Radcliffe, J, Thomas, A, Bradford, R, Lioy, J, Tapia, IE, Assadsangabi, R, Shults, J & Marcus, CL 2016, 'Evolution of obstructive sleep apnea in infants with cleft palate and micrognathia', Journal of Clinical Sleep Medicine, vol. 12, no. 7, pp. 979-987. https://doi.org/10.5664/jcsm.5930
Cielo CM, Taylor JA, Vossough A, Radcliffe J, Thomas A, Bradford R et al. Evolution of obstructive sleep apnea in infants with cleft palate and micrognathia. Journal of Clinical Sleep Medicine. 2016 Jan 1;12(7):979-987. https://doi.org/10.5664/jcsm.5930
Cielo, Christopher M. ; Taylor, Jesse A. ; Vossough, Arastoo ; Radcliffe, Jerilynn ; Thomas, Allison ; Bradford, Ruth ; Lioy, Janet ; Tapia, Ignacio E. ; Assadsangabi, Reza ; Shults, Justine ; Marcus, Carole L. / Evolution of obstructive sleep apnea in infants with cleft palate and micrognathia. In: Journal of Clinical Sleep Medicine. 2016 ; Vol. 12, No. 7. pp. 979-987.
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abstract = "Study Objectives: Children with craniofacial anomalies are a heterogeneous group at high risk for obstructive sleep apnea (OSA). However, the prevalence and structural predictors of OSA in this population are unknown. We hypothesized that infants with micrognathia would have more significant OSA than those with isolated cleft palate ± cleft lip (ICP), and those with ICP would have more significant OSA than controls. We postulated that OSA severity would correlate with reduced mandibular size, neurodevelopmental scores, and growth. Methods: Prospective cohort study. 15 infants with ICP, 19 with micrognathia, and 9 controls were recruited for polysomnograms, neurodevelopmental testing, cephalometrics (ICP and micrognathia groups) at baseline and a follow-up at 6 mo. Results: Baseline apnea-hypopnea index (AHI) [median (range)] of the micrognathia group [20.1 events/h (0.8, 54.7)] was greater than ICP [3.2 (0.3, 30.7)] or controls [3.1 (0.5, 23.3)] (p = 0.001). Polysomnographic findings were similar between ICP and controls. Controls had a greater AHI than previously reported in the literature. Cephalometric measures of both midface hypoplasia and micrognathia correlated with OSA severity. Neurodevelopment was similar among groups. OSA improved with growth in participants with ICP and postoperatively in infants with micrognathia. Conclusions: Micrognathia, but not ICP, was associated with more significant OSA compared to controls. Both midface and mandibular hypoplasia contribute to OSA in these populations. OSA improved after surgical correction in most infants with micrognathia, and improved without intervention before palate repair in infants with ICP.",
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AU - Bradford, Ruth

AU - Lioy, Janet

AU - Tapia, Ignacio E.

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