Evidence that the antigen of autologous immune complex glomerulonephritis of rats is a mannose- or glucose-containing glycoprotein

Sudesh P Makker

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Chemical nature of the brush border antigen (BBAg) of the autologous immune complex glomerulonephritis (AIC) of rats was investigated by a histochemical method utilizing indirect immunofluorescence. Fresh frozen rat kidney sections, a specific antibody to BBAg (BBAb), purified lectins (concanavalin A, Ricin II, wheat germ hemagglutinin) and a specific sugar, α-methyl-D-mannopyranoside were used. The reaction of the specific antibody BBAb to its antigen BBAg on tissue sections was blocked by concanavalin A but not by Ricin II and wheat germ agglutinin. This blockade was reversed by α-methyl-D-mannopyranoside. These results suggest that the antigen of AIC of rats is a mannose or glucose containing glycoprotein.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume163
Issue number1
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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