Evidence of vertical transmission of Neospora sp infection in dairy cattle

Mark L Anderson, James P. Reynolds, Joan D Rowe, Karen W. Sverlow, Andrea E. Packham, Bradd C. Barr, Patricia A Conrad

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Objective - To determine whether heifers with naturally acquired congenital exposure to Neospora sp would transmit the infection to their offspring during gestation. Design - Prospective cohort study. Animals - Neonatal heifers on a dairy with a history of Neospora sp infections were selected for the study on the basis of their serum titers to Neospora sp, as determined by the use of indirect fluorescent antibody testing. Seropositive heifers (n = 25) had titers ≥ 1:5,120 and seronegative heifers (25) had titers ≤ 1:80. All heifers were raised and bred on the dairy, and samples were obtained from heifers and their calves at the time of calving. Procedure - Blood samples were tested for Neospora sp antibodies. Histologic evaluations, Neospora sp immunohistochemical examinations, and protozoal culturing were performed on samples obtained from selected offspring (second-generation calves). Results - Seropositive heifers gave birth to calves with titers ≥ 1:1,280 to Neospora sp. All offspring from seropositive heifers that were necropsied had evidence of Neospora sp infection. All seronegative heifers and their offspring had titers < 1:80 to Neospora sp. Clinical Implications - Congenitally acquired Neospora sp infection can persist in clinically normal heifers and be transmitted transplacentally to their offspring. Vertical transmission can be a way by which neosporosis is maintained in herds.

Original languageEnglish (US)
Pages (from-to)1169-1172
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume210
Issue number8
StatePublished - Apr 15 1997

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Neospora
dairy cattle
heifers
Infection
infection
calves
dairies
Newborn Animals
neosporosis
Antibodies
antibody detection
blood serum
cohort studies
sampling
Cohort Studies
calving
neonates
Parturition
Prospective Studies
herds

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evidence of vertical transmission of Neospora sp infection in dairy cattle. / Anderson, Mark L; Reynolds, James P.; Rowe, Joan D; Sverlow, Karen W.; Packham, Andrea E.; Barr, Bradd C.; Conrad, Patricia A.

In: Journal of the American Veterinary Medical Association, Vol. 210, No. 8, 15.04.1997, p. 1169-1172.

Research output: Contribution to journalArticle

Anderson, Mark L ; Reynolds, James P. ; Rowe, Joan D ; Sverlow, Karen W. ; Packham, Andrea E. ; Barr, Bradd C. ; Conrad, Patricia A. / Evidence of vertical transmission of Neospora sp infection in dairy cattle. In: Journal of the American Veterinary Medical Association. 1997 ; Vol. 210, No. 8. pp. 1169-1172.
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