Abstract
Experimental and theoretical evidence is provided that indicates the presence of inclusion complexes in the gas phase when cyclodextrin and amino acid mixtures are electrosprayed into a Fourier transform mass spectrometer. A guest exchange reaction that is enantiospecific is used to probe the structure of the gas-phase complex. Chiral selectivity is affected by both the size of the guest and the size of the cavity. These observations are based on a selected number of amino acids with various hosts. The experimental results are supported by molecular dynamics calculations. We further conclude that rather than nonspecific complexes, amino acid-cyclodextrin complexes produced in solution maintain the included structure even in the gas phase.
Original language | English (US) |
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Pages (from-to) | 6884-6890 |
Number of pages | 7 |
Journal | Journal of the American Chemical Society |
Volume | 122 |
Issue number | 29 |
DOIs | |
State | Published - Jul 26 2000 |
ASJC Scopus subject areas
- Chemistry(all)