Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression

Janet E Foley; C. M. Leutenegger; Stephen J. Dumler; Niels C Pedersen; John E Madigan

doi:10.1016/S0147-9571(02)00023-1

Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression

Janet E Foley, C. M. Leutenegger, Stephen J. Dumler, Niels C Pedersen, John E Madigan

Medicine and Epidemiology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.

Original language	English (US)
Pages (from-to)	103-113
Number of pages	11
Journal	Comparative Immunology, Microbiology and Infectious Diseases
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/S0147-9571(02)00023-1
State	Published - Mar 2003

Keywords

Acquired immune deficiency syndrome
Anaplasma phagocytophila
Feline immunodeficiency virus
Human granulocytic ehrlichiosis

ASJC Scopus subject areas

Animal Science and Zoology
Immunology
Microbiology
veterinary(all)

Access to Document

10.1016/S0147-9571(02)00023-1

Cite this

Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression. / Foley, Janet E; Leutenegger, C. M.; Dumler, Stephen J.; Pedersen, Niels C ; Madigan, John E.

In: Comparative Immunology, Microbiology and Infectious Diseases, Vol. 26, No. 2, 03.2003, p. 103-113.

Research output: Contribution to journal › Article › peer-review

@article{d20fd0a33eaf4800838dc463ca72d54c,

title = "Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression",

abstract = "Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.",

keywords = "Acquired immune deficiency syndrome, Anaplasma phagocytophila, Feline immunodeficiency virus, Human granulocytic ehrlichiosis",

author = "Foley, {Janet E} and Leutenegger, {C. M.} and Dumler, {Stephen J.} and Pedersen, {Niels C} and Madigan, {John E}",

year = "2003",

month = mar,

doi = "10.1016/S0147-9571(02)00023-1",

language = "English (US)",

volume = "26",

pages = "103--113",

journal = "Comparative Immunology, Microbiology and Infectious Diseases",

issn = "0147-9571",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression

AU - Foley, Janet E

AU - Leutenegger, C. M.

AU - Dumler, Stephen J.

AU - Pedersen, Niels C

AU - Madigan, John E

PY - 2003/3

Y1 - 2003/3

N2 - Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.

AB - Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.

KW - Acquired immune deficiency syndrome

KW - Anaplasma phagocytophila

KW - Feline immunodeficiency virus

KW - Human granulocytic ehrlichiosis

UR - http://www.scopus.com/inward/record.url?scp=0037367916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037367916&partnerID=8YFLogxK

U2 - 10.1016/S0147-9571(02)00023-1

DO - 10.1016/S0147-9571(02)00023-1

M3 - Article

C2 - 12493491

AN - SCOPUS:0037367916

VL - 26

SP - 103

EP - 113

JO - Comparative Immunology, Microbiology and Infectious Diseases

JF - Comparative Immunology, Microbiology and Infectious Diseases

SN - 0147-9571

IS - 2

ER -

Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this