Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression

Janet E Foley, C. M. Leutenegger, Stephen J. Dumler, Niels C Pedersen, John E Madigan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume26
Issue number2
DOIs
StatePublished - Mar 2003

Fingerprint

Anaplasma phagocytophilum
Ehrlichiosis
Feline Immunodeficiency Virus
granulocytic ehrlichiosis
immunosuppression
Immunosuppression
Cats
immune response
cats
human granulocytic ehrlichiosis
immunocompromised population
ehrlichiosis
emerging diseases
interleukin-10
infection
Emerging Communicable Diseases
Opportunistic Infections
Immunocompromised Host
vaccines
Interleukin-10

Keywords

  • Acquired immune deficiency syndrome
  • Anaplasma phagocytophila
  • Feline immunodeficiency virus
  • Human granulocytic ehrlichiosis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • Microbiology
  • veterinary(all)

Cite this

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title = "Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression",
abstract = "Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.",
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author = "Foley, {Janet E} and Leutenegger, {C. M.} and Dumler, {Stephen J.} and Pedersen, {Niels C} and Madigan, {John E}",
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T1 - Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression

AU - Foley, Janet E

AU - Leutenegger, C. M.

AU - Dumler, Stephen J.

AU - Pedersen, Niels C

AU - Madigan, John E

PY - 2003/3

Y1 - 2003/3

N2 - Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.

AB - Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.

KW - Acquired immune deficiency syndrome

KW - Anaplasma phagocytophila

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