Abstract
Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-113 |
| Number of pages | 11 |
| Journal | Comparative Immunology, Microbiology and Infectious Diseases |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2003 |
Fingerprint
Keywords
- Acquired immune deficiency syndrome
- Anaplasma phagocytophila
- Feline immunodeficiency virus
- Human granulocytic ehrlichiosis
ASJC Scopus subject areas
- Animal Science and Zoology
- Immunology
- Microbiology
- veterinary(all)
Cite this
Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression. / Foley, Janet E; Leutenegger, C. M.; Dumler, Stephen J.; Pedersen, Niels C; Madigan, John E.
In: Comparative Immunology, Microbiology and Infectious Diseases, Vol. 26, No. 2, 03.2003, p. 103-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression
AU - Foley, Janet E
AU - Leutenegger, C. M.
AU - Dumler, Stephen J.
AU - Pedersen, Niels C
AU - Madigan, John E
PY - 2003/3
Y1 - 2003/3
N2 - Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.
AB - Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease in which some patients experience unusual opportunistic infections. In this study, cats infected with the HGE agent, Anaplasma phagocytophila s.l., had clinical granulocytic ehrlichiosis (GE), anti-nuclear antibodies and increased IFN-γ mRNA. In FIV-immunosuppressed cats with GE, there was upregulated IL-10 transcription but not IFN-γ. Cats with FIV had poor response to vaccines, regardless of GE status. This preliminary report demonstrates that cats with FIV-infection make a good model of chrlichiosis in an immunocompromised host, and that viral immunosuppression may not increase the severity of ehrlichiosis but may attenuate immune responses to the pathogen.
KW - Acquired immune deficiency syndrome
KW - Anaplasma phagocytophila
KW - Feline immunodeficiency virus
KW - Human granulocytic ehrlichiosis
UR - http://www.scopus.com/inward/record.url?scp=0037367916&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037367916&partnerID=8YFLogxK
U2 - 10.1016/S0147-9571(02)00023-1
DO - 10.1016/S0147-9571(02)00023-1
M3 - Article
C2 - 12493491
AN - SCOPUS:0037367916
VL - 26
SP - 103
EP - 113
JO - Comparative Immunology, Microbiology and Infectious Diseases
JF - Comparative Immunology, Microbiology and Infectious Diseases
SN - 0147-9571
IS - 2
ER -