Evidence for an intrinsic renal tubular defect in mice with genetic hypophosphatemic rickets

Larry D Cowgill, S. Goldfarb, K. Lau, E. Slatopolsky, Z. S. Agus

Research output: Contribution to journalArticle

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Abstract

To investigate the role of parathyroid hormone (PTH) and(or) an intrinsic renal tubular reabsorptive defect for phosphate in mice with hereditary hypophosphatemic rickets, the authors performed clearance and micropuncture studies in hypophosphatemic mutants and nonaffected littermate controls. Increased fractional excretion of phosphate in mutants (47.2±4 vs. 30.8±2% in controls) was associated with reduced fractional and absolute reabsorption in the proximal convoluted tubule and more distal sites. Acute thyroparathyroidectomy (TPTX) increased phosphate reabsorption in both mutants and controls with a fall in fractional phosphate excretion to ≃7.5% in both groups indicating that PTH modified the degree of phosphaturia in the intact mutants. Absolute reabsorption in the proximal tubule and beyond remained reduced in the mutants, however, possibly because of the reduced filtered load. Serum PTH levels were the same in intact mutants and normals as was renal cortical adenylate cyclase activity both before and after PTH stimulation. Hereditary hypophosphatemia in the mouse is associated with a renal tubular defect in phosphate reabsorption, which is independent of PTH and therefore represents a specific intrinsic abnormality of phosphate transport.

Original languageEnglish (US)
Pages (from-to)1203-1210
Number of pages8
JournalUnknown Journal
Volume63
Issue number6
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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Hypophosphatemic Rickets
Parathyroid Hormone
Phosphates
Kidney
Familial Hypophosphatemic Rickets
Familial Hypophosphatemia
Hypophosphatemia
Punctures
Adenylyl Cyclases
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evidence for an intrinsic renal tubular defect in mice with genetic hypophosphatemic rickets. / Cowgill, Larry D; Goldfarb, S.; Lau, K.; Slatopolsky, E.; Agus, Z. S.

In: Unknown Journal, Vol. 63, No. 6, 01.01.1979, p. 1203-1210.

Research output: Contribution to journalArticle

Cowgill, Larry D ; Goldfarb, S. ; Lau, K. ; Slatopolsky, E. ; Agus, Z. S. / Evidence for an intrinsic renal tubular defect in mice with genetic hypophosphatemic rickets. In: Unknown Journal. 1979 ; Vol. 63, No. 6. pp. 1203-1210.
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