Evidence for a single pedigree source of the hyperkalemic periodic paralysis susceptibility gene in Quarter Horses

A. T. Bowling, G. Byrns, Sharon Spier

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The pedigree origin of a base pair substitution in the horse muscle sodium channel gene that confers susceptibility to the muscle disease hyperkalemic periodic paralysis (HYPP) was investigated with a set of 978 Quarter Horses. The horses were chosen at random, based on a collection of blood samples taken between 1989 and 1991 to meet parentage testing requirements, primarily but not exclusively from breeding stallions. The frequency of Quarter Horses positive for the base pair substitution, all heterozygotes, was 4.4%, which corresponds to an allelic frequency of 0.02. All horses positive for the gene traced to a single previously identified stallion as first, second or third generation descendants. A higher frequency of the HYPP susceptibility trait than expected by random occurrence was found among his descendants in this study.

Original languageEnglish (US)
Pages (from-to)279-281
Number of pages3
JournalAnimal Genetics
Volume27
Issue number4
StatePublished - Aug 1996

Fingerprint

Hyperkalemic Periodic Paralysis
Quarter Horse
paralysis
Pedigree
pedigree
Horses
stallions
horses
Genes
sodium channels
genes
Base Pairing
muscular diseases
parentage
gene frequency
heterozygosity
Muscles
Sodium Channels
muscles
Heterozygote

Keywords

  • genetic disease
  • horse
  • HYPP
  • PCR-RFLP

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Genetics(clinical)

Cite this

Evidence for a single pedigree source of the hyperkalemic periodic paralysis susceptibility gene in Quarter Horses. / Bowling, A. T.; Byrns, G.; Spier, Sharon.

In: Animal Genetics, Vol. 27, No. 4, 08.1996, p. 279-281.

Research output: Contribution to journalArticle

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