Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides).

Linda J Lowenstine, N. W. Lerche, J. L. Yee, A. Uyeda, M. B. Jennings, R. J. Munn, H. M. McClure, D. C. Anderson, P. N. Fultz, M. B. Gardner

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Abstract

A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalJournal of Medical Primatology
Volume21
Issue number1
StatePublished - Jan 1992

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Macaca arctoides
immunosuppression
Macaca
lymphoma
etiology
Lymphoma
Lentivirus
Macaca mulatta
Lentivirus Infections
Betaretrovirus
Human immunodeficiency virus 2
HIV-2
Serology
Human immunodeficiency virus 1
retrospective studies
lymph nodes
HIV-1
epidemiology
Epidemiology
Retrospective Studies

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides). / Lowenstine, Linda J; Lerche, N. W.; Yee, J. L.; Uyeda, A.; Jennings, M. B.; Munn, R. J.; McClure, H. M.; Anderson, D. C.; Fultz, P. N.; Gardner, M. B.

In: Journal of Medical Primatology, Vol. 21, No. 1, 01.1992, p. 1-14.

Research output: Contribution to journalArticle

Lowenstine, LJ, Lerche, NW, Yee, JL, Uyeda, A, Jennings, MB, Munn, RJ, McClure, HM, Anderson, DC, Fultz, PN & Gardner, MB 1992, 'Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides).', Journal of Medical Primatology, vol. 21, no. 1, pp. 1-14.
Lowenstine, Linda J ; Lerche, N. W. ; Yee, J. L. ; Uyeda, A. ; Jennings, M. B. ; Munn, R. J. ; McClure, H. M. ; Anderson, D. C. ; Fultz, P. N. ; Gardner, M. B. / Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides). In: Journal of Medical Primatology. 1992 ; Vol. 21, No. 1. pp. 1-14.
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