Abstract
A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-14 |
| Number of pages | 14 |
| Journal | Journal of Medical Primatology |
| Volume | 21 |
| Issue number | 1 |
| State | Published - Jan 1992 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides). / Lowenstine, Linda J; Lerche, N. W.; Yee, J. L.; Uyeda, A.; Jennings, M. B.; Munn, R. J.; McClure, H. M.; Anderson, D. C.; Fultz, P. N.; Gardner, M. B.
In: Journal of Medical Primatology, Vol. 21, No. 1, 01.1992, p. 1-14.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides).
AU - Lowenstine, Linda J
AU - Lerche, N. W.
AU - Yee, J. L.
AU - Uyeda, A.
AU - Jennings, M. B.
AU - Munn, R. J.
AU - McClure, H. M.
AU - Anderson, D. C.
AU - Fultz, P. N.
AU - Gardner, M. B.
PY - 1992/1
Y1 - 1992/1
N2 - A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.
AB - A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026451792&partnerID=8YFLogxK
M3 - Article
VL - 21
SP - 1
EP - 14
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 1
ER -