Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides).

Linda J Lowenstine, N. W. Lerche, J. L. Yee, A. Uyeda, M. B. Jennings, R. J. Munn, H. M. McClure, D. C. Anderson, P. N. Fultz, M. B. Gardner

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40 Scopus citations

Abstract

A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalJournal of Medical Primatology
Volume21
Issue number1
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Lowenstine, L. J., Lerche, N. W., Yee, J. L., Uyeda, A., Jennings, M. B., Munn, R. J., McClure, H. M., Anderson, D. C., Fultz, P. N., & Gardner, M. B. (1992). Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides). Journal of Medical Primatology, 21(1), 1-14.