Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD

Timothy E Albertson; Willis S. Bowman; Richart W Harper; Regina M. Godbout; Susan Murin

doi:10.2147/COPD.S191845

Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD

Timothy E Albertson, Willis S. Bowman, Richart W Harper, Regina M. Godbout, Susan Murin

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The use of inhaled, fixed-dose, long-acting muscarinic antagonists (LAMA) combined with long-acting, beta2-adrenergic receptor agonists (LABA) has become a mainstay in the maintenance treatment of chronic obstructive pulmonary disease (COPD). One of the fixed-dose LAMA/LABA combinations is the dry powder inhaler (DPI) of umeclidinium bromide (UMEC) and vilanterol trifenatate (VI) (62.5 µg/25 µg) approved for once-a-day maintenance treatment of COPD. This paper reviews the use of fixed-dose combination LAMA/LABA agents focusing on the UMEC/VI DPI inhaler in the maintenance treatment of COPD. The fixed-dose combination LAMA/LABA inhaler offers a step beyond a single inhaled maintenance agent but is still a single device for the COPD patient having frequent COPD exacerbations and persistent symptoms not well controlled on one agent. Currently available clinical trials suggest that the once-a-day DPI of UMEC/VI is well-tolerated, safe and non-inferior or better than other currently available inhaled fixed-dose LAMA/LABA combinations for COPD.

Original language	English (US)
Pages (from-to)	1251-1265
Number of pages	15
Journal	International journal of chronic obstructive pulmonary disease
Volume	14
DOIs	https://doi.org/10.2147/COPD.S191845
State	Published - Jan 1 2019

Keywords

COPD
fixed-dose combination inhalers
LABA
LAMA
long-acting beta2-adrenergic agonists
long-acting muscarinic antagonists
umeclidinium bromide
vilanterol trifenatate

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Health Policy
Public Health, Environmental and Occupational Health

Access to Document

10.2147/COPD.S191845

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Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD. / Albertson, Timothy E; Bowman, Willis S.; Harper, Richart W; Godbout, Regina M.; Murin, Susan.

In: International journal of chronic obstructive pulmonary disease, Vol. 14, 01.01.2019, p. 1251-1265.

Research output: Contribution to journal › Review article › peer-review

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abstract = "The use of inhaled, fixed-dose, long-acting muscarinic antagonists (LAMA) combined with long-acting, beta2-adrenergic receptor agonists (LABA) has become a mainstay in the maintenance treatment of chronic obstructive pulmonary disease (COPD). One of the fixed-dose LAMA/LABA combinations is the dry powder inhaler (DPI) of umeclidinium bromide (UMEC) and vilanterol trifenatate (VI) (62.5 µg/25 µg) approved for once-a-day maintenance treatment of COPD. This paper reviews the use of fixed-dose combination LAMA/LABA agents focusing on the UMEC/VI DPI inhaler in the maintenance treatment of COPD. The fixed-dose combination LAMA/LABA inhaler offers a step beyond a single inhaled maintenance agent but is still a single device for the COPD patient having frequent COPD exacerbations and persistent symptoms not well controlled on one agent. Currently available clinical trials suggest that the once-a-day DPI of UMEC/VI is well-tolerated, safe and non-inferior or better than other currently available inhaled fixed-dose LAMA/LABA combinations for COPD.",

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