Evidence-Based Heart Failure Medications and Cognition

Lisa C. Bratzke, Debra K. Moser, Michele M. Pelter, Steven M. Paul, Thomas S Nesbitt, Lawton S. Cooper, Kathleen A. Dracup

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: The etiology of cognitive impairment in heart failure (HF) is controversial and likely multifactorial. Physicians may hesitate to prescribe evidence-based HF medication because of concerns related to potential negative changes in cognition among a population that is already frequently impaired. We conducted a study to determine if prescription of evidence-based HF medications (specifically, β-blockers, angiotensin-converting enzyme inhibitors, angiotensin-receptor blocking agents, diuretics, and aldosterone inhibitors) was associated with cognition in a large HF sample.

METHODS: A total of 612 patients completed baseline data collection for the Rural Education to Improve Outcomes in Heart Failure clinical trial, including information about medications. Global cognition was evaluated using the Mini-Cog.

RESULTS: The sample mean (SD) age was 66 (13) years, 58% were men, and 89% were white. Global cognitive impairment was identified in 206 (34%) of the 612 patients. Prescription of evidence-based HF medications was not related to global cognitive impairment in this sample. This relationship was maintained even after adjusting for potential confounders (eg, age, education, and comorbid burden).

CONCLUSION: Prescription of evidence-based HF medications is not related to low scores on a measure of global cognitive function in rural patients with HF.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalThe Journal of cardiovascular nursing
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2016

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Cognition
Heart Failure
Prescriptions
Education
Angiotensin Receptors
Aldosterone
Angiotensin-Converting Enzyme Inhibitors
Diuretics
Clinical Trials
Physicians
Population
Cognitive Dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Bratzke, L. C., Moser, D. K., Pelter, M. M., Paul, S. M., Nesbitt, T. S., Cooper, L. S., & Dracup, K. A. (2016). Evidence-Based Heart Failure Medications and Cognition. The Journal of cardiovascular nursing, 31(1), 62-68. https://doi.org/10.1097/JCN.0000000000000216

Evidence-Based Heart Failure Medications and Cognition. / Bratzke, Lisa C.; Moser, Debra K.; Pelter, Michele M.; Paul, Steven M.; Nesbitt, Thomas S; Cooper, Lawton S.; Dracup, Kathleen A.

In: The Journal of cardiovascular nursing, Vol. 31, No. 1, 01.01.2016, p. 62-68.

Research output: Contribution to journalArticle

Bratzke, LC, Moser, DK, Pelter, MM, Paul, SM, Nesbitt, TS, Cooper, LS & Dracup, KA 2016, 'Evidence-Based Heart Failure Medications and Cognition', The Journal of cardiovascular nursing, vol. 31, no. 1, pp. 62-68. https://doi.org/10.1097/JCN.0000000000000216
Bratzke, Lisa C. ; Moser, Debra K. ; Pelter, Michele M. ; Paul, Steven M. ; Nesbitt, Thomas S ; Cooper, Lawton S. ; Dracup, Kathleen A. / Evidence-Based Heart Failure Medications and Cognition. In: The Journal of cardiovascular nursing. 2016 ; Vol. 31, No. 1. pp. 62-68.
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