Abstract
The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 342-354 |
| Number of pages | 13 |
| Journal | Journal of the International Neuropsychological Society |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2004 |
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Keywords
- Activities of daily living
- Dementia
- Neuropsychology
- Older adults
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Psychiatry and Mental health
- Neuroscience(all)
- Psychology(all)
Cite this
Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling hispanic and Non-Hispanic older adults. / Tomaszewski Farias, Sarah E; Mungas, Dan M; Reed, Bruce R; Haan, Mary N.; Jagust, William J.
In: Journal of the International Neuropsychological Society, Vol. 10, No. 3, 05.2004, p. 342-354.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling hispanic and Non-Hispanic older adults
AU - Tomaszewski Farias, Sarah E
AU - Mungas, Dan M
AU - Reed, Bruce R
AU - Haan, Mary N.
AU - Jagust, William J.
PY - 2004/5
Y1 - 2004/5
N2 - The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.
AB - The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.
KW - Activities of daily living
KW - Dementia
KW - Neuropsychology
KW - Older adults
UR - http://www.scopus.com/inward/record.url?scp=2942685033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942685033&partnerID=8YFLogxK
U2 - 10.1017/S1355617704103020
DO - 10.1017/S1355617704103020
M3 - Article
C2 - 15147592
AN - SCOPUS:2942685033
VL - 10
SP - 342
EP - 354
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
SN - 1355-6177
IS - 3
ER -