Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling hispanic and Non-Hispanic older adults

Sarah E Tomaszewski Farias, Dan M Mungas, Bruce R Reed, Mary N. Haan, William J. Jagust

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.

Original languageEnglish (US)
Pages (from-to)342-354
Number of pages13
JournalJournal of the International Neuropsychological Society
Volume10
Issue number3
DOIs
StatePublished - May 2004

Fingerprint

Independent Living
Hispanic Americans
Neuroimaging
Aptitude
Ethnic Groups
Cognition
Language
White Matter

Keywords

  • Activities of daily living
  • Dementia
  • Neuropsychology
  • Older adults

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

@article{ed697e810d0046b4a93b204d0b53bb3c,
title = "Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling hispanic and Non-Hispanic older adults",
abstract = "The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23{\%} of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18{\%} of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.",
keywords = "Activities of daily living, Dementia, Neuropsychology, Older adults",
author = "{Tomaszewski Farias}, {Sarah E} and Mungas, {Dan M} and Reed, {Bruce R} and Haan, {Mary N.} and Jagust, {William J.}",
year = "2004",
month = "5",
doi = "10.1017/S1355617704103020",
language = "English (US)",
volume = "10",
pages = "342--354",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "3",

}

TY - JOUR

T1 - Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling hispanic and Non-Hispanic older adults

AU - Tomaszewski Farias, Sarah E

AU - Mungas, Dan M

AU - Reed, Bruce R

AU - Haan, Mary N.

AU - Jagust, William J.

PY - 2004/5

Y1 - 2004/5

N2 - The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.

AB - The purpose of this study was to examine how a specific informant-based measure of everyday functioning, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE; Jorm & Korten, 1988) relates to cognition and structural neuroimaging in a large multicultural, multilingual sample of Caucasians and Hispanics. Cognitive variables included selected subtests from the Spanish and English Neuropsychological Assessment Scales (SENAS; Mungas et al., 2000): Verbal Memory, Object Naming, Verbal Attention Span, Verbal Conceptual Thinking, and Pattern Recognition. The association between the IQCODE and selected neuroimaging variables, hippocampal volume and white matter hyperintensity, was evaluated in a subsample of English- and Spanish-speaking Hispanic individuals. The cognitive variables showed strong bivariate relationships with the IQCODE, although only Verbal Memory and Object Naming independently predicted level of functional ability. Verbal Memory was the strongest predictor of functional status, accounting for 23% of the variance in the IQCODE. White matter hyperintensity was also independently related to the IQCODE, accounting for 18% of the variance. Hippocampal volume was related to the IQCODE in a simple bivariate analysis, but was not an independent predictor of reported functional status after controlling for age. The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups.

KW - Activities of daily living

KW - Dementia

KW - Neuropsychology

KW - Older adults

UR - http://www.scopus.com/inward/record.url?scp=2942685033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942685033&partnerID=8YFLogxK

U2 - 10.1017/S1355617704103020

DO - 10.1017/S1355617704103020

M3 - Article

C2 - 15147592

AN - SCOPUS:2942685033

VL - 10

SP - 342

EP - 354

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 3

ER -