Everyday cognition in prodromal huntington disease

Janet K. Williams, Ji In Kim, Nancy Downing, Sarah E Tomaszewski Farias, Deborah L. Harrington, Jeffrey D. Long, James A. Mills, Jane S. Paulsen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Assessment of daily functions affected by cognitive loss in prodromal Huntington's disease (HD) is necessary in practice and clinical trials. We evaluated baseline and longitudinal sensitivity of the Everyday Cognition (ECog) scales in prodromal HD and compared self- and companion-ratings. Method: Everyday cognition was self-assessed by 850 participants with prodromal HD and 768 companions. We examined internal structure using confirmatory factor analysis (CFA) on baseline data. For longitudinal analysis, we stratified participants into Low, Medium, and High disease progression groups. We examined ECog scores for group differences and participant-and-companion differences using linear mixed effects regression (LMER). Comparison with the Total Functional Capacity (TFC) scale was made. Results: CFA revealed good fit of a 5-factor model having a global factor (total score), and subfactors (subscales) of memory, language, visuospatial perception, and executive function. At study entry, participants and companions in the Medium and High groups reported significantly worsened everyday cognition as well as significant functional decline over time. Losses became more pronounced and participant and companion ratings diverged as individuals progressed. TFC showed significant functional loss over time in the High group but not in the Medium group. Conclusions: Disease progression is associated with reduced self- and companion-reported everyday cognition in prodromal HD participants who are less than 13 years to estimated motor onset. Our findings suggest companion ratings are more sensitive than participants' for detecting longitudinal change in daily cognitive function. ECog appears more sensitive to specific functional changes in the prodrome of HD than the TFC.

Original languageEnglish (US)
Pages (from-to)255-267
Number of pages13
JournalNeuropsychology
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2015

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Huntington Disease
Cognition
Statistical Factor Analysis
Disease Progression
Companionship
Executive Function
Language
Clinical Trials
Rating

Keywords

  • Activities of daily living
  • Cognition
  • Ecog
  • Everyday functioning
  • Prodromal huntington's disease
  • Tfc

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Williams, J. K., Kim, J. I., Downing, N., Tomaszewski Farias, S. E., Harrington, D. L., Long, J. D., ... Paulsen, J. S. (2015). Everyday cognition in prodromal huntington disease. Neuropsychology, 29(2), 255-267. https://doi.org/10.1037/neu0000102

Everyday cognition in prodromal huntington disease. / Williams, Janet K.; Kim, Ji In; Downing, Nancy; Tomaszewski Farias, Sarah E; Harrington, Deborah L.; Long, Jeffrey D.; Mills, James A.; Paulsen, Jane S.

In: Neuropsychology, Vol. 29, No. 2, 01.03.2015, p. 255-267.

Research output: Contribution to journalArticle

Williams, JK, Kim, JI, Downing, N, Tomaszewski Farias, SE, Harrington, DL, Long, JD, Mills, JA & Paulsen, JS 2015, 'Everyday cognition in prodromal huntington disease', Neuropsychology, vol. 29, no. 2, pp. 255-267. https://doi.org/10.1037/neu0000102
Williams JK, Kim JI, Downing N, Tomaszewski Farias SE, Harrington DL, Long JD et al. Everyday cognition in prodromal huntington disease. Neuropsychology. 2015 Mar 1;29(2):255-267. https://doi.org/10.1037/neu0000102
Williams, Janet K. ; Kim, Ji In ; Downing, Nancy ; Tomaszewski Farias, Sarah E ; Harrington, Deborah L. ; Long, Jeffrey D. ; Mills, James A. ; Paulsen, Jane S. / Everyday cognition in prodromal huntington disease. In: Neuropsychology. 2015 ; Vol. 29, No. 2. pp. 255-267.
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