Abstract
Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including α-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce α-defensins. The α-defensins are cysteine-rich cadonic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell α-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell α-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Gastrointestinal and Liver Physiology |
| Volume | 289 |
| Issue number | 2 52-2 |
| DOIs | |
| State | Published - Aug 2005 |
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Keywords
- Antimicrobial peptide
- Crohn's disease
- Innate immunity
ASJC Scopus subject areas
- Gastroenterology
- Physiology
Cite this
Events at the host-microbial interface of the gastrointestinal tract. V. Paneth cell α-defensins in intestinal host defense. / Bevins, Charles L.
In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 289, No. 2 52-2, 08.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Events at the host-microbial interface of the gastrointestinal tract. V. Paneth cell α-defensins in intestinal host defense
AU - Bevins, Charles L
PY - 2005/8
Y1 - 2005/8
N2 - Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including α-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce α-defensins. The α-defensins are cysteine-rich cadonic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell α-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell α-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.
AB - Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including α-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce α-defensins. The α-defensins are cysteine-rich cadonic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell α-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell α-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.
KW - Antimicrobial peptide
KW - Crohn's disease
KW - Innate immunity
UR - http://www.scopus.com/inward/record.url?scp=22544488093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22544488093&partnerID=8YFLogxK
U2 - 10.1152/ajpgi.00079.2005
DO - 10.1152/ajpgi.00079.2005
M3 - Article
C2 - 16014978
AN - SCOPUS:22544488093
VL - 289
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 2 52-2
ER -