Abstract
Background: The prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients. Objectives: (1) To determine the patterns of weight change in dogs with appendicular osteosarcoma treated with amputation and single-agent carboplatin during the course of adjuvant chemotherapy; and (2) to determine whether postoperative weight change is a negative prognostic indicator for survival time in dogs with osteosarcoma. Animals: Eighty-eight dogs diagnosed with appendicular osteosarcoma. Animals were accrued from 3 veterinary teaching hospitals. Methods: Retrospective, multi-institutional study. Dogs diagnosed with appendicular osteosarcoma and treated with limb amputation followed by a minimum of 4 doses of single-agent carboplatin were included. Data analyzed in each patient included signalment, tumor site, preoperative serum alkaline phosphatase activity (ALP), and body weight (kg) at each carboplatin treatment. Results: A slight increase in weight occurred over the course of chemotherapy, but this change was not statistically significant. Weight change did not have a significant effect on survival. Institution, patient sex, and serum ALP activity did not have a significant effect on survival. Conclusions and Clinical Importance: Weight change was not a prognostic factor in these dogs, and weight loss alone may not be a suitable method of determining cancer cachexia in dogs with appendicular osteosarcoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1159-1162 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Internal Medicine |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2017 |
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Keywords
- Cachexia
- Canine
- Chemotherapy
- Oncology
ASJC Scopus subject areas
- veterinary(all)
Cite this
Evaluation of Weight Change During Carboplatin Therapy in Dogs With Appendicular Osteosarcoma. / Story, A. L.; Boston, S. E.; Kilkenny, J. J.; Singh, A.; Woods, J. P.; Culp, William T; Skorupski, Katherine A; Lu, X.
In: Journal of Veterinary Internal Medicine, Vol. 31, No. 4, 01.07.2017, p. 1159-1162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of Weight Change During Carboplatin Therapy in Dogs With Appendicular Osteosarcoma
AU - Story, A. L.
AU - Boston, S. E.
AU - Kilkenny, J. J.
AU - Singh, A.
AU - Woods, J. P.
AU - Culp, William T
AU - Skorupski, Katherine A
AU - Lu, X.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background: The prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients. Objectives: (1) To determine the patterns of weight change in dogs with appendicular osteosarcoma treated with amputation and single-agent carboplatin during the course of adjuvant chemotherapy; and (2) to determine whether postoperative weight change is a negative prognostic indicator for survival time in dogs with osteosarcoma. Animals: Eighty-eight dogs diagnosed with appendicular osteosarcoma. Animals were accrued from 3 veterinary teaching hospitals. Methods: Retrospective, multi-institutional study. Dogs diagnosed with appendicular osteosarcoma and treated with limb amputation followed by a minimum of 4 doses of single-agent carboplatin were included. Data analyzed in each patient included signalment, tumor site, preoperative serum alkaline phosphatase activity (ALP), and body weight (kg) at each carboplatin treatment. Results: A slight increase in weight occurred over the course of chemotherapy, but this change was not statistically significant. Weight change did not have a significant effect on survival. Institution, patient sex, and serum ALP activity did not have a significant effect on survival. Conclusions and Clinical Importance: Weight change was not a prognostic factor in these dogs, and weight loss alone may not be a suitable method of determining cancer cachexia in dogs with appendicular osteosarcoma.
AB - Background: The prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients. Objectives: (1) To determine the patterns of weight change in dogs with appendicular osteosarcoma treated with amputation and single-agent carboplatin during the course of adjuvant chemotherapy; and (2) to determine whether postoperative weight change is a negative prognostic indicator for survival time in dogs with osteosarcoma. Animals: Eighty-eight dogs diagnosed with appendicular osteosarcoma. Animals were accrued from 3 veterinary teaching hospitals. Methods: Retrospective, multi-institutional study. Dogs diagnosed with appendicular osteosarcoma and treated with limb amputation followed by a minimum of 4 doses of single-agent carboplatin were included. Data analyzed in each patient included signalment, tumor site, preoperative serum alkaline phosphatase activity (ALP), and body weight (kg) at each carboplatin treatment. Results: A slight increase in weight occurred over the course of chemotherapy, but this change was not statistically significant. Weight change did not have a significant effect on survival. Institution, patient sex, and serum ALP activity did not have a significant effect on survival. Conclusions and Clinical Importance: Weight change was not a prognostic factor in these dogs, and weight loss alone may not be a suitable method of determining cancer cachexia in dogs with appendicular osteosarcoma.
KW - Cachexia
KW - Canine
KW - Chemotherapy
KW - Oncology
UR - http://www.scopus.com/inward/record.url?scp=85019262407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019262407&partnerID=8YFLogxK
U2 - 10.1111/jvim.14724
DO - 10.1111/jvim.14724
M3 - Article
C2 - 28503759
AN - SCOPUS:85019262407
VL - 31
SP - 1159
EP - 1162
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 4
ER -