Evaluation of various contrast agents for improved arthrography

Richard W Katzberg, Francis A. Burgener, Harry W. Fischer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


In the canine knee joint the monomer methylglucamine iothalamate, the dimer methylglucamine iocarmate, and the nonionic contrast agent metrizamide were examined for use in arthrography. A total of 104 injections were per formed with equal iodine concentrations (280-282 mg/ml) and volumes (4 ml) of the three contrast agents. These were evaluated using radiographic comparison and iodine estimations of the joint fluid at various times after injection. Radiographically the dimer was superior, followed by metrizamidc and then the monomer. The greatest amount of total iodine within the joint fluid at various times after injection was found with the dimer. Iodine concentrations in the joint fluid were similar for the dimer and metrizamide, both greater than with the monomer.

Original languageEnglish (US)
Pages (from-to)528-533
Number of pages6
JournalInvestigative Radiology
Issue number6
StatePublished - 1976
Externally publishedYes


  • Arthrography
  • Contrast agents
  • Methyl glucamine iocarmate
  • Methylglucaminc iothalamatc
  • Metrizamide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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