Evaluation of urodynamic procedures in female cats anesthetized with low and high doses of isoflurane and propofol

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective - To compare effects of isoflurane and propofol on the cystometrogram and urethral pressure profile (UPP) in healthy female cats. Animals - 6 healthy female cats. Procedures - Cats were anesthetized, and a consistent plane of anesthesia was maintained with low and high doses of isoflurane and propofol. A 6-F double-lumen urinary catheter was placed aseptically in the urethra for cystometrogram and UPP measurements. Threshold pressure and volume were recorded for cystometrograms. Maximum urethral pressure for smooth and skeletal muscle portions of the urethra, maximum urethral closure pressure, and functional profile length were measured during each UPP measurement. Heart rate and respiratory rate were recorded. Results - Cats anesthetized with the low dose of propofol had consistent detrusor reflexes, compared with results for the other anesthetics. Mean ± SD threshold pressure, volume per unit of body weight, and compliance were 75.7 ± 16.3 cm H2O, 8.3 ± 3.2 mL/kg, and 0.5 ± 0.4 mL/cm H2O, respectively, for low-dose propofol. Anesthesia with either dose of propofol caused a significantly higher percentage change in heart rate during the cystometrogram, compared with results for anesthesia with isoflurane. Maximal urethral pressure in the area corresponding to skeletal muscle and the maximum urethral closure pressure were significantly higher for the low dose of propofol, compared with results for the high dose of propofol. Conclusions and Clinical Relevance - The low-dose propofol regimen was the easiest to titrate and maintain and yielded diagnostic-quality detrusor reflexes in all 6 cats. Anesthetic depth should be titrated appropriately when performing urodynamic procedures.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume70
Issue number2
DOIs
StatePublished - Feb 2009

Fingerprint

Urodynamics
Isoflurane
isoflurane
Propofol
Cats
cats
Pressure
dosage
anesthesia
urethra
Anesthesia
Urethra
reflexes
Reflex
Anesthetics
skeletal muscle
heart rate
Skeletal Muscle
Heart Rate
depth of anesthesia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{98ff41c6e03d42ecb2985c3bd4daa41c,
title = "Evaluation of urodynamic procedures in female cats anesthetized with low and high doses of isoflurane and propofol",
abstract = "Objective - To compare effects of isoflurane and propofol on the cystometrogram and urethral pressure profile (UPP) in healthy female cats. Animals - 6 healthy female cats. Procedures - Cats were anesthetized, and a consistent plane of anesthesia was maintained with low and high doses of isoflurane and propofol. A 6-F double-lumen urinary catheter was placed aseptically in the urethra for cystometrogram and UPP measurements. Threshold pressure and volume were recorded for cystometrograms. Maximum urethral pressure for smooth and skeletal muscle portions of the urethra, maximum urethral closure pressure, and functional profile length were measured during each UPP measurement. Heart rate and respiratory rate were recorded. Results - Cats anesthetized with the low dose of propofol had consistent detrusor reflexes, compared with results for the other anesthetics. Mean ± SD threshold pressure, volume per unit of body weight, and compliance were 75.7 ± 16.3 cm H2O, 8.3 ± 3.2 mL/kg, and 0.5 ± 0.4 mL/cm H2O, respectively, for low-dose propofol. Anesthesia with either dose of propofol caused a significantly higher percentage change in heart rate during the cystometrogram, compared with results for anesthesia with isoflurane. Maximal urethral pressure in the area corresponding to skeletal muscle and the maximum urethral closure pressure were significantly higher for the low dose of propofol, compared with results for the high dose of propofol. Conclusions and Clinical Relevance - The low-dose propofol regimen was the easiest to titrate and maintain and yielded diagnostic-quality detrusor reflexes in all 6 cats. Anesthetic depth should be titrated appropriately when performing urodynamic procedures.",
author = "Cohen, {Todd A.} and Westropp, {Joellen L} and Kass, {Philip H} and Pypendop, {Bruno H}",
year = "2009",
month = "2",
doi = "10.2460/ajvr.70.2.290",
language = "English (US)",
volume = "70",
pages = "290--296",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "2",

}

TY - JOUR

T1 - Evaluation of urodynamic procedures in female cats anesthetized with low and high doses of isoflurane and propofol

AU - Cohen, Todd A.

AU - Westropp, Joellen L

AU - Kass, Philip H

AU - Pypendop, Bruno H

PY - 2009/2

Y1 - 2009/2

N2 - Objective - To compare effects of isoflurane and propofol on the cystometrogram and urethral pressure profile (UPP) in healthy female cats. Animals - 6 healthy female cats. Procedures - Cats were anesthetized, and a consistent plane of anesthesia was maintained with low and high doses of isoflurane and propofol. A 6-F double-lumen urinary catheter was placed aseptically in the urethra for cystometrogram and UPP measurements. Threshold pressure and volume were recorded for cystometrograms. Maximum urethral pressure for smooth and skeletal muscle portions of the urethra, maximum urethral closure pressure, and functional profile length were measured during each UPP measurement. Heart rate and respiratory rate were recorded. Results - Cats anesthetized with the low dose of propofol had consistent detrusor reflexes, compared with results for the other anesthetics. Mean ± SD threshold pressure, volume per unit of body weight, and compliance were 75.7 ± 16.3 cm H2O, 8.3 ± 3.2 mL/kg, and 0.5 ± 0.4 mL/cm H2O, respectively, for low-dose propofol. Anesthesia with either dose of propofol caused a significantly higher percentage change in heart rate during the cystometrogram, compared with results for anesthesia with isoflurane. Maximal urethral pressure in the area corresponding to skeletal muscle and the maximum urethral closure pressure were significantly higher for the low dose of propofol, compared with results for the high dose of propofol. Conclusions and Clinical Relevance - The low-dose propofol regimen was the easiest to titrate and maintain and yielded diagnostic-quality detrusor reflexes in all 6 cats. Anesthetic depth should be titrated appropriately when performing urodynamic procedures.

AB - Objective - To compare effects of isoflurane and propofol on the cystometrogram and urethral pressure profile (UPP) in healthy female cats. Animals - 6 healthy female cats. Procedures - Cats were anesthetized, and a consistent plane of anesthesia was maintained with low and high doses of isoflurane and propofol. A 6-F double-lumen urinary catheter was placed aseptically in the urethra for cystometrogram and UPP measurements. Threshold pressure and volume were recorded for cystometrograms. Maximum urethral pressure for smooth and skeletal muscle portions of the urethra, maximum urethral closure pressure, and functional profile length were measured during each UPP measurement. Heart rate and respiratory rate were recorded. Results - Cats anesthetized with the low dose of propofol had consistent detrusor reflexes, compared with results for the other anesthetics. Mean ± SD threshold pressure, volume per unit of body weight, and compliance were 75.7 ± 16.3 cm H2O, 8.3 ± 3.2 mL/kg, and 0.5 ± 0.4 mL/cm H2O, respectively, for low-dose propofol. Anesthesia with either dose of propofol caused a significantly higher percentage change in heart rate during the cystometrogram, compared with results for anesthesia with isoflurane. Maximal urethral pressure in the area corresponding to skeletal muscle and the maximum urethral closure pressure were significantly higher for the low dose of propofol, compared with results for the high dose of propofol. Conclusions and Clinical Relevance - The low-dose propofol regimen was the easiest to titrate and maintain and yielded diagnostic-quality detrusor reflexes in all 6 cats. Anesthetic depth should be titrated appropriately when performing urodynamic procedures.

UR - http://www.scopus.com/inward/record.url?scp=60749108716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60749108716&partnerID=8YFLogxK

U2 - 10.2460/ajvr.70.2.290

DO - 10.2460/ajvr.70.2.290

M3 - Article

C2 - 19231964

AN - SCOPUS:60749108716

VL - 70

SP - 290

EP - 296

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 2

ER -