Abstract
Tissue engineering of the temporomandibular joint disc could be a great value in treatments that require discectomy. Potential benefit has been found in the use of three growth factors: insulin-like growth factor-I, basic fibroblast growth factor and transforming growth factor-β1 in maintaining disc-like tissue in culture. In the present study, these three growth factors were combined in pairs and tested at two different concentrations over a 6-week period. All combinations of the growth factors appear to be beneficial since only three-quarters of the control constructs (without growth factors) retained mechanical integrity, compared with the majority of constructs exposed to growth factors. Importantly, the concentrations of the presented growth factors had a significant impact on the cellularity of constructs at Week 6. When a high concentration of the two growth factors was used, at least twice as many cells remained in the constructs compared with controls.
Original language | English (US) |
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Pages (from-to) | 215-221 |
Number of pages | 7 |
Journal | Archives of Oral Biology |
Volume | 51 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2006 |
Externally published | Yes |
Keywords
- Growth factors
- Tissue engineering
- TMJ disc
ASJC Scopus subject areas
- Dentistry(all)