Evaluation of three growth factors in combinations of two for temporomandibular joint disc tissue engineering

A. J. Almarza, K. A. Athanasiou

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Tissue engineering of the temporomandibular joint disc could be a great value in treatments that require discectomy. Potential benefit has been found in the use of three growth factors: insulin-like growth factor-I, basic fibroblast growth factor and transforming growth factor-β1 in maintaining disc-like tissue in culture. In the present study, these three growth factors were combined in pairs and tested at two different concentrations over a 6-week period. All combinations of the growth factors appear to be beneficial since only three-quarters of the control constructs (without growth factors) retained mechanical integrity, compared with the majority of constructs exposed to growth factors. Importantly, the concentrations of the presented growth factors had a significant impact on the cellularity of constructs at Week 6. When a high concentration of the two growth factors was used, at least twice as many cells remained in the constructs compared with controls.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalArchives of Oral Biology
Volume51
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Keywords

  • Growth factors
  • Tissue engineering
  • TMJ disc

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Evaluation of three growth factors in combinations of two for temporomandibular joint disc tissue engineering'. Together they form a unique fingerprint.

  • Cite this